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CNDP2 Antibodies
AND CNDP2 ELISA kits, CNDP2 Proteins
Many biological assays use antibodies to detect CNDP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CNDP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CNDP2 antibodies...
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CNDP2 Infographic by Boster Bio
All CNDP2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$523
Cat # M06331
100 µl
Cat # M06331
100 µl
Human, Mouse, Rat
IF, IHC, WB
$523
Cat # M06331-1
100 µl
Cat # M06331-1
100 µl
CNDP2 Overview
Facts about Cytosolic non-specific dipeptidase.
Cytosolic non-specific dipeptidase (CNDP2)
Hydrolyzes a variety of dipeptides such as L-carnosine but has a strong taste for Cys-Gly (PubMed:19346245). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway.
An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower degree of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568). Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880).
Gene Information
| Human | |
|---|---|
| Gene Name: | CNDP2 |
| Uniprot: | Q96KP4 |
| Entrez: | 55748 |
Family
| Belongs to: |
|---|
| peptidase M20A family |
Alternative Names
CN2; CN2cytosolic non-specific dipeptidase; CNDP dipeptidase 2 (metallopeptidase M20 family); CNDP dipeptidase 2; CNDP2; CPGL; CPGLcytosolic nonspecific dipeptidase; FLJ10830; HsT2298; PEPA; PEPAEC 3.4.13.18; Peptidase AGlutamate carboxypeptidase-like protein 1
Molecular Weight
Mass (kDA):
52.878 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q22.3 |
| Sequence: | 18; NC_000018.10 (74496363..74523454) |
Tissue Specificity
Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes (PubMed:12473676). Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. Down-regulated in gastric cancer tissues (at protein level) (PubMed:24395568).
Subcellular Localizations
Cytoplasm.
Diseases
- Diabetic Nephropathy
- Kidney Diseases
- Diabetes Mellitus
- Nervousness
- Kidney Failure, Chronic
- Diabetes Mellitus, Non-insulin-dependent
- Diabetes Mellitus, Insulin-dependent
- Neoplasm Metastasis
- Classical Swine Fever
- Neoplasm Invasiveness
- Parkinson Disease
- Carcinoma
- Vascular System Injuries
Pathways
- Cell Growth
- Localization
- Cell Migration
- Cell Cycle
- Cellular Localization
- Pathogenesis
PTMs
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CNDP2
bosterbio.com/bosterbio-gene-info-cards/CNDP2
References
PMID: 12473676 by Teufel M., et al. Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase.
PMID: 17121880 by Zhang P., et al. Identification of carboxypeptidase of glutamate like-B as a candidate suppressor in cell growth and metastasis in human hepatocellular carcinoma.