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- Table of Contents
Facts about Cell division cycle and apoptosis regulator protein 1.
Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity).
Human | |
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Gene Name: | CCAR1 |
Uniprot: | Q8IX12 |
Entrez: | 55749 |
Belongs to: |
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No superfamily |
CARP-1; CARP1MGC44628; Cell cycle and apoptosis regulatory protein 1; cell division cycle and apoptosis regulator 1; cell division cycle and apoptosis regulator protein 1; Death inducer with SAP domain; DIS; FLJ10590; RP11-437A18.1
Mass (kDA):
132.821 kDA
Human | |
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Location: | 10q21.3 |
Sequence: | 10; NC_000010.11 (68721239..68792377) |
Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.
Cytoplasm, perinuclear region.
PMID: 12816952 by Rishi A.K., et al. Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437.
PMID: 18722177 by Kim J.H., et al. CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes.