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Chemokine-like receptor 1 Antibodies
AND CMKLR1 ELISA kits, Chemokine-like receptor 1 Proteins
Many biological assays use antibodies to detect Chemokine-like receptor 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Chemokine-like receptor 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Chemokine-like receptor 1 antibodies...
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CMKLR1 Overview
Facts about Chemokine-like receptor 1.
Chemokine-like receptor 1 (CMKLR1)
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid based molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis.
Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Positively regulates adipogenesis and adipocyte metabolism.
Gene Information
| Human | |
|---|---|
| Gene Name: | CMKLR1 |
| Uniprot: | Q99788 |
| Entrez: | 1240 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
CHEMERINR; chemokine receptor-like 1; chemokine-like receptor 1; ChemR23; cmklr1; Dez; Gpcr27; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ; MGC126105; MGC126106; orphan G-protein coupled receptor, Dez
Molecular Weight
Mass (kDA):
42.322 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q23.3 |
| Sequence: | 12; NC_000012.12 (108288044..108339347, complement) |
Tissue Specificity
Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Inflammation
- Obesity
- Cardiovascular Diseases
- Diabetes Mellitus
- Neoplasms
- Insulin Resistance
- Psoriasis
- Diabetes Mellitus, Non-insulin-dependent
- Tissue Adhesions
- Peritonitis
- Pneumonia
- Immunologic Deficiency Syndromes
- Malignant Neoplasms
Pathways
- Chemotaxis
- Secretion
- Cell Migration
- Coagulation
- Immune Response
- Pathogenesis
- Glucose Homeostasis
- Inflammatory Response
- Cell Proliferation
- Transport
- Phagocytosis
- Fibrinolysis
- Bone Development
PTMs
- Phosphorylation
Research Areas
- GPCR
- Immunology
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CMKLR1
bosterbio.com/bosterbio-gene-info-cards/CMKLR1
References
PMID: 9144535 by Methner A., et al. A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development.
PMID: 9603476 by Samson M., et al. ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains.