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- Table of Contents
Facts about Leukotriene B4 receptor 1.
Receptor for extracellular ATP > UTP and ADP.
The activity of this receptor is mediated by G proteins that activate a phosphatidylinositol-calcium second messenger system.May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune reaction.
Human | |
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Gene Name: | LTB4R |
Uniprot: | Q15722 |
Entrez: | 1241 |
Belongs to: |
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G-protein coupled receptor 1 family |
BLT1; chemokine receptor-like 1; CMKRL1; Leukotriene B4 R1; leukotriene B4 receptor; Leukotriene B4R1; LTB4R; LTB4R1; LTBR1; P2Y purinoceptor 7; purinergic receptor P2Y, G-protein coupled, 7
Mass (kDA):
37.557 kDA
Human | |
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Location: | 14q12 |
Sequence: | 14; NC_000014.9 (24311502..24318036) |
Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues.
Cell membrane; Multi-pass membrane protein.
PMID: 8702478 by Akbar G.K.M., et al. Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells.
PMID: 8558062 by Raport C.J., et al. New members of the chemokine receptor gene family.
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