Claspin Antibodies

AND CLSPN ELISA kits, Claspin Proteins

Many biological assays use antibodies to detect Claspin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Claspin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Claspin antibodies...

We validate the specificity of these antibodies to Claspin by testing them on tissues known to express CLSPN positively and negatively. Browse below to find the CLSPN antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CLSPN Infographic by Boster Bio

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Anti-Claspin CLSPN Antibody

Human

ELISA, WB

$380
Cat # A03249
100ul

CLSPN Overview

Facts about Claspin.

CLSPN 3D structure. Source: alphafold

Claspin (CLSPN)

Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage caused by both ionizing and UV irradiation. Adapter protein that binds to BRCA1 and the checkpoint kinase CHEK1 and eases the ATR- dependent phosphorylation of both proteins.

Can also bind specifically to branched DNA structures and may connect with S- phase chromatin following formation of the pre-replication complicated (pre-RC). This may indicate a role for this protein as a sensor that monitors the integrity of DNA replication forks.

Gene Information

Human
Gene Name:	CLSPN
Uniprot:	Q9HAW4
Entrez:	63967

Family

Belongs to:

claspin family

Alternative Names

claspin homolog (Xenopus laevis); claspin homolog; Claspin; CLSPN; hClaspin; MGC131612; MGC131613; MGC131615

Molecular Weight

Mass (kDA):
151.094 kDA

Genomic Context


Human

Location:	1p34.3
Sequence:	1; NC_000001.11 (35720213..35769985, complement)

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Genotoxic Stress
Ataxia
Neoplasms
Ataxia Telangiectasia
Telangiectasis
Malignant Neoplasm Of Breast
Mammary Neoplasms
Genomic Instability
Osteosarcoma
Cell Transformation, Neoplastic
Colorectal Neoplasms

Von Hippel-lindau Syndrome
Trinucleotide Repeat Expansion
Inflammatory Bowel Diseases
Hepatitis B
Bone Neoplasms
Intestinal Diseases

Interacting Proteins

CDC45
CDK9
CHEK1
FZR1

Pathways

Dna Replication
Cell Cycle
Mitosis
Dna Replication Checkpoint
Dna Repair
S Phase
Dna Damage Checkpoint
Cell Proliferation
Cell Cycle Arrest
Localization
Cell Cycle Checkpoint
Proteolysis
Replication Fork Protection

Cell Death
Cell Growth
Rna Interference
Double-strand Break Repair
Sister Chromatid Cohesion
Interphase
Response To Hydroxyurea

PTMs

Phosphorylation
Cleavage

Ubiquitination
Dephosphorylation

Methylation

Research Areas

Cancer
Cell Cycle and Replication
DNA Repair

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLSPN

References

PMID: 11090622 by Kumagai A., et al. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts.

PMID: 12766152 by Chini C.C.S., et al. Human claspin is required for replication checkpoint control.