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CLEC4M Antibodies
AND CLEC4M ELISA kits, CLEC4M Proteins
Many biological assays use antibodies to detect CLEC4M, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLEC4M in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLEC4M antibodies...
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CLEC4M Infographic by Boster Bio
All CLEC4M Products
Product
Figures
Specificity
Applications
Price
Human
IHC
$523
Cat # M02814
100 µl
Cat # M02814
100 µl
Human
IHC, WB
$523
Cat # M02814-1
100 µl
Cat # M02814-1
100 µl
CLEC4M Overview
Facts about C-type lectin domain family 4 member M.
C-type lectin domain family 4 member M (CLEC4M)
Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens that are subsequently degraded in lysosomal compartments.
Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. .
Gene Information
| Human | |
|---|---|
| Gene Name: | CLEC4M |
| Uniprot: | Q9H2X3 |
| Entrez: | 10332 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD209L; CD209L1; CD209Ldendritic cell-specific ICAM-3-grabbing nonintegrin 2; CD299 antigenMGC129964; CD299; CLEC4M; C-type lectin domain family 4, member M; DC-SIGN2; DC-SIGN2CD209 antigen-like protein 1; DCSIGNR; DC-SIGNR; DC-SIGNRDC-SIGN-related protein; DCSIGNRMGC47866; Dendritic cell-specific ICAM-3-grabbing non-integrin 2; HP10347; liver/lymph node-specific ICAM-3 grabbing non-integrin; Liver/lymph node-specific ICAM-3-grabbing non-integrin; LSIGN; L-SIGN; LSIGNC-type lectin domain family 4 member M; mannose binding C-type lectin DC-SIGNR
Molecular Weight
Mass (kDA):
45.35 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.2 |
| Sequence: | 19; NC_000019.10 (7763052..7770559) |
Tissue Specificity
Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells.
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type II membrane protein.; [Isoform 2]: Cell membrane; Single-pass type II membrane protein.; [Isoform 3]: Cell membrane; Single-pass type II membrane protein.; [Isoform 5]: Secreted.; [Isoform 6]: Secreted.; [Isoform 7]: Secreted.; [Isoform 10]: Secreted.
Diseases
- Hiv Infections
- Tissue Adhesions
- Immunologic Deficiency Syndromes
- Virus Diseases
- Hepatitis
- Hepatitis C
- Severe Acute Respiratory Syndrome
- Vertical Disease Transmission
- Infective Disorder
- Hemorrhagic Fever, Ebola
- Communicable Diseases
- Acquired Immunodeficiency Syndrome
Pathways
- Glycosylation
- Pathogenesis
- Tropism
- Immune Response
- Cell Adhesion
- Transport
- Gene Silencing
- Induction Of Apoptosis
- Interaction With Host
- Cytokine Secretion
- Complement Activation
- Blood Circulation
- Endocytosis
PTMs
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLEC4M
bosterbio.com/bosterbio-gene-info-cards/CLEC4M
References
PMID: 10072769 by Yokoyama-Kobayashi M., et al. Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank.
PMID: 10975799 by Soilleux E.J., et al. DC-SIGN, a related gene, DC-SIGNR, and CD23 form a cluster on 19p13.