This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about C-type lectin domain family 2 member A.
May modulate the capacity of T-cells to home to lymph nodes throughout SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.
Human | |
---|---|
Gene Name: | CLEC2A |
Uniprot: | Q6UVW9 |
Entrez: | 387836 |
Belongs to: |
---|
No superfamily |
CLEC2A C-type lectin domain family 2, member A ; CLEC2A; CLEC-2A; KACL; PILAR; UNQ5792
Mass (kDA):
19.972 kDA
Human | |
---|---|
Location: | 12p13.31 |
Sequence: | 12; NC_000012.12 (9882733..9932430, complement) |
Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine, peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8(+), B-lymphocytes and naive CD4(+) T-cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer (NK) cells.
Cell membrane; Single-pass type II membrane protein.
PMID: 18550855 by Huarte E., et al. PILAR is a novel modulator of human T-cell expansion.
PMID: 18046548 by Spreu J., et al. CLEC2A: a novel, alternatively spliced and skin-associated member of the NKC-encoded AICL-CD69-LLT1 family.