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Cisd2 Antibodies
AND Cisd2 ELISA kits, Cisd2 Proteins
Many biological assays use antibodies to detect Cisd2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cisd2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cisd2 antibodies...
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Cisd2 Infographic by Boster Bio
All Cisd2 Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A06387-1
100 μg/vial
Cat # A06387-1
100 μg/vial
Human, Mouse, Rat
IHC, WB
$523
Cat # M06387
100 µl
Cat # M06387
100 µl
Cisd2 Overview
Facts about CDGSH iron-sulfur domain-containing protein 2.
CDGSH iron-sulfur domain-containing protein 2 (Cisd2)
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy in the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is needed for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy.
Contributes to BIK-initiated autophagy, although it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its role as the regulator of autophagy (By similarity).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Cisd2 |
| Uniprot: | Q9CQB5 |
| Entrez: | 67006 |
Family
| Belongs to: |
|---|
| CISD protein family |
Alternative Names
CDGSH iron sulfur domain 2; CDGSH iron-sulfur domain-containing protein 2; CDGSH2; Endoplasmic reticulum intermembrane small protein; ERISWFS2; Miner1Wolfram syndrome 2; mitoNEET related 1; MitoNEET-related 1 protein; NAF-1; Nutrient-deprivation autophagy factor-1; ZCD2CDGSH iron sulfur domain-containing protein 2; zinc finger, CDGSH-type domain 2
Molecular Weight
Mass (kDA):
15.242 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 3|3 G3 |
| Sequence: | 3; |
Tissue Specificity
Brain.
Diseases
- Wolfram Syndrome
- Premature Aging Syndrome
- Optic Atrophy
- Complete Hearing Loss
- Muscle Degeneration
- Neurodegenerative Disorders
- Atrophy
- Diabetes Mellitus
- Abnormal Degeneration
- Degenerative Disorder
- Mitochondrial Diseases
Pathways
- Aging
- Autophagy
- Cell Death
- Pathogenesis
- Autophagic Cell Death
- Regulation Of Autophagy
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Cisd2
bosterbio.com/bosterbio-gene-info-cards/Cisd2
References
PMID: 17029606 by Boucquey M.F.A., et al. Noxp20 and Noxp70, two new markers of early neuronal differentiation, detected in teratocarcinoma-derived neuroectodermic precursor cells.
PMID: 19451219 by Chen Y.F., et al. Cisd2 deficiency drives premature aging and causes mitochondria- mediated defects in mice.