CHTF8 Antibodies

AND CHTF8 ELISA kits, CHTF8 Proteins

Many biological assays use antibodies to detect CHTF8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHTF8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHTF8 antibodies...

We validate the specificity of these antibodies to CHTF8 by testing them on tissues known to express CHTF8 positively and negatively. Browse below to find the CHTF8 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CHTF8 Infographic by Boster Bio

All CHTF8 Products

Product

Figures

Specificity

Applications

Price

CHTF8 (NM_001039690) Human Recombinant Protein

$1249
Cat # PROTP0CG13
20 µg

CHTF8 (NM_001039690) Human Over-expression Lysate

Human

$628
Cat # LS054921
100 µg

CHTF8 Overview

Facts about Chromosome transmission fidelity protein 8 homolog.

CHTF8 3D structure. Source: alphafold

Chromosome transmission fidelity protein 8 homolog (CHTF8)

Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication variable C (CTF18-RFC), which is made up of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5.

The CTF18-RFC complex binds to single- stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA.

Gene Information

Human
Gene Name:	CHTF8
Uniprot:	P0CG13
Entrez:	54921

Family

Belongs to:

CTF8 family

Alternative Names

chromosome transmission fidelity protein 8 homolog; CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae); CTF8hCTF8; Decreased expression in renal and prostate cancer protein; DERPCchromosome transmission fidelity factor 8 homolog; FLJ20400

Molecular Weight

Mass (kDA):
13.314 kDA

Genomic Context


Human

Location:	16q22.1
Sequence:	16; NC_000016.10 (69118010..69132588, complement)

Tissue Specificity

Ubiquitously expressed, with abundant expression in kidney, skeletal muscle, testis, liver, ovary, and heart and moderate expression in prostate. Expression is significantly reduced in renal and prostate tumors. No differential expression in breast cancer cells, between lobular carcinoma and normal lobules.

Subcellular Localizations

Nucleus. Associates with chromatin during S phase.

Diseases

Malignant Neoplasm Of Prostate
Cell Transformation, Neoplastic
Prostatic Neoplasms
Malignant Neoplasms
Neoplasms
Kidney Neoplasm

Lymphocytic Choriomeningitis

Pathways

Cell Growth

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHTF8

References

PMID: 12766176 by Merkle C.J., et al. Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment.

PMID: 12930902 by Bermudez V.P., et al. The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA.