CHTF18 Antibodies

AND CHTF18 ELISA kits, CHTF18 Proteins

Many biological assays use antibodies to detect CHTF18, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHTF18 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHTF18 antibodies...

We validate the specificity of these antibodies to CHTF18 by testing them on tissues known to express CHTF18 positively and negatively. Browse below to find the CHTF18 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CHTF18 Infographic by Boster Bio

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CHTF18 (NM_022092) Human Over-expression Lysate

Human

$628
Cat # LS063922
100 µg

CHTF18 Overview

Facts about Chromosome transmission fidelity protein 18 homolog.

CHTF18 3D structure. Source: alphafold

Chromosome transmission fidelity protein 18 homolog (CHTF18)

Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Part of one of those cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5.

The CTF18-RFC complex binds to single- stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18- RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA.

Gene Information

Human
Gene Name:	CHTF18
Uniprot:	Q8WVB6
Entrez:	63922

Family

Belongs to:

activator 1 small subunits family

Alternative Names

C16orf41; C321D2.2; C321D2.3 (novel protein); C321D2.3; C321D2.4 (novel protein); CHL12C321D2.4; chromosome 16 open reading frame 41; chromosome transmission fidelity protein 18 homolog; Ctf18; CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae); EC 3.6.1; hCTF18; homolog of yeast CHL12; RUVBL; some homology with holliday junction DNA helicase RUVB like

Molecular Weight

Mass (kDA):
107.383 kDA

Genomic Context


Human

Location:	16p13.3
Sequence:	16; NC_000016.10 (788620..798074)

Subcellular Localizations

Nucleus. Associates with chromatin during S phase.

Diseases

Subfertility

Pathways

Sister Chromatid Cohesion
Dna Replication
Establishment Of Sister Chromatid Cohesion
Cell Development
Germ Cell Development
S Phase
Cell Proliferation
Mitosis
Dna Repair
Spermatogenesis

Double-strand Break Repair
Prophase
Germ Cell Proliferation
Meiosis

PTMs

Acetylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHTF18

References

PMID: 12766176 by Merkle C.J., et al. Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment.

PMID: 12930902 by Bermudez V.P., et al. The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA.