CHRNB4 Antibodies

AND CHRNB4 ELISA kits, CHRNB4 Proteins

Many biological assays use antibodies to detect CHRNB4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHRNB4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHRNB4 antibodies...

We validate the specificity of these antibodies to CHRNB4 by testing them on tissues known to express CHRNB4 positively and negatively. Browse below to find the CHRNB4 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CHRNB4 Infographic by Boster Bio

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Anti-ACHB4 CHRNB4 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A02984
100ul

CHRNB4 Overview

Facts about Neuronal acetylcholine receptor subunit beta-4.

CHRNB4 3D structure. Source: alphafold

Neuronal acetylcholine receptor subunit beta-4 (CHRNB4)

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. .

Gene Information

Human
Gene Name:	CHRNB4
Uniprot:	P30926
Entrez:	1143

Family

Belongs to:

ligand-gated ion channel (TC 1.A.9) family

Alternative Names

cholinergic receptor, nicotinic, beta 4; cholinergic receptor, nicotinic, beta polypeptide 4; neuronal acetylcholine receptor subunit beta-4; neuronal nicotinic receptor beta 4 subunit

Molecular Weight

Mass (kDA):
56.38 kDA

Genomic Context


Human

Location:	15q25.1
Sequence:	15; NC_000015.10 (78623282..78655586, complement)

Subcellular Localizations

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Diseases

Nicotine Dependence
Tobacco Use Disorder
Malignant Neoplasms
Malignant Neoplasm Of Lung
Lung Neoplasms
Dysequilibrium Syndrome
Epilepsy
Epilepsy, Frontal Lobe
Substance-related Disorders
Lung Diseases
Lung Diseases, Obstructive

Adenocarcinoma
Depressive Disorder
Chronic Obstructive Airway Disease
Cholangiocarcinoma
Sclerosis

Pathways

Pathogenesis
Response To Nicotine
Localization
Chromosome Localization
Cell Proliferation
Cell Growth
Cell Adhesion
Dna Hypermethylation
Catecholamine Secretion
Temperature Homeostasis
Fertilization
Mrna Transcription
Cognition

Dna Methylation
Synaptic Transmission
Cellular Response To Nicotine
Response To Alcohol
Demethylation
Methylation
Nucleosome Assembly

PTMs

Phosphorylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHRNB4

References

PMID: 8906617 by Elliott K.J., et al. Comparative structure of human neuronal alpha 2-alpha 7 and beta 2- beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.

PMID: 9203638 by Gerzanich V., et al. Orphan' alpha6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor.