CHRNA5 Antibodies

Neuronal acetylcholine receptor subunit alpha-5 (CHRNA5)

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. .

Gene Information

Human
Gene Name:	CHRNA5
Uniprot:	P30532
Entrez:	1138

Family

Belongs to:
ligand-gated ion channel (TC 1.A.9) family

Alternative Names

Cholinergic receptor, neuronal nicotinic, alpha polypeptide-5; cholinergic receptor, nicotinic, alpha 5; cholinergic receptor, nicotinic, alpha polypeptide 5; CHRNA5; LNCR2; NACHRA5; neuronal acetylcholine receptor subunit alpha-5; neuronal nicotinic acetylcholine receptor, alpha5 subunit; Nicotinic Acetylcholine R alpha 5; Nicotinic Acetylcholine Ra5

Molecular Weight

Mass (kDA):
53.054 kDA

Genomic Context

Human
Location:	15q25.1
Sequence:	15; NC_000015.10 (78565520..78595269)

Subcellular Localizations

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Diseases

• Nicotine Dependence
• Tobacco Use Disorder
• Malignant Neoplasms
• Malignant Neoplasm Of Lung
• Lung Neoplasms
• Dysequilibrium Syndrome
• Chronic Obstructive Airway Disease
• Lung Diseases
• Lung Diseases, Obstructive
• Adenocarcinoma
• Epilepsy

• Epilepsy, Frontal Lobe
• Cholangiocarcinoma
• Substance-related Disorders
• Non-small Cell Lung Carcinoma
• Malignant Squamous Cell Neoplasm
• Pulmonary Emphysema

Interacting Proteins

• CHRNB2

Pathways

• Pathogenesis
• Localization
• Chromosome Localization
• Cell Proliferation
• Cognition
• Response To Nicotine
• Cell Adhesion
• Habituation
• Prepulse Inhibition
• Catecholamine Secretion
• Fertilization
• Aging
• Cellular Response To Nicotine

• Response To Alcohol
• Startle Response
• Methylation
• Sensitization
• Cell Cycle
• Acrosome Reaction
• Cell Growth

PTMs

• Phosphorylation

• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHRNA5

Best Uses Of The CHRNA5 Marker

If you're curious about Steven Boster, you can learn about his biography. You'll discover his influence on molecular biology and his interest in histology. In addition, you'll discover his career. Read on to find out more about his work. Below are some of his most important contributions to molecular biology. The CHRNA5 Marker is a gene found in the cytoplasm of eukaryotic cells.

Histology

The CHRNA5 gene is not neuron-specific, as it also occurs in non-neuronal cells. The gene is expressed in all types of lung cancer, ranging from small to large, and is expressed in both neuronal and non-neuronal cell lines. The gene may be associated with lung cancer by its presence in lung tissue. Histology of the CHRNA5 marker may provide new insight into the pathogenesis of the disease.

The CHRNA5/A3/B4 gene encodes a subunit of the nAChR receptor. There are three SNPs in the gene promoter associated with risk of lung cancer, COPD, and nicotine dependence. These SNPs are located in the CHRNB4 3'-untranslated region, which participates in the stability of mRNA. Although CHRNA5/A3/B4 is a novel marker for lung cancer, it is a useful diagnostic tool for the diagnosis of lung cancer.

The SNP rs6495309 (C>T) is part of a cluster of genes on chromosome 15q25.1. The C genotype has been associated with an increased risk of lung cancer in smokers, while the T genotype has no correlation with risk of non-small-cell lung cancer in non-smokers. The CC genotype is associated with a higher risk in subjects aged 60 and older.

The CHRNA3-CHRNA5 gene cluster is associated with a risk of NSCLC in Chinese population. The phenotypic effects of CHRNA3 and PHACTR2 have also been identified in the Chinese population. These findings are backed by numerous studies examining the CHRNA5 gene cluster. The CHRNA3-CHRNA5 gene cluster is associated with increased risk of lung cancer.

Career

The CHRNA5 gene code for the a5 subunit of nicotinic acetylcholine receptors. The association of the marker with behavioral risks is based on two independent studies. One showed a significant association with aversion to nicotine, while the other did not. Despite this association, further research is needed to determine the role of this gene in determining the risk of heavy smoking.

Influence in molecular biology

This study examined the role of the CHRNA5 polymorphism in schizophrenia susceptibility. Although its exact cause is unknown, there are several hypotheses that link genetic variation in CHRNA5 with schizophrenia. These hypotheses include a possible role of CHRNA5 polymorphism in the development of schizophrenia and its relation with other neurological disorders. In this study, we examined the role of the CHRNA5 polymorphism in schizophrenia susceptibility in the Chinese population.

The CHRNA5 gene is expressed in the cytoplasm by methylating DNA, a process that regulates gene expression. In humans, DNA methylation regulates gene expression by regulating CpGs. However, CHRNA5 expression is highly regulated by smoking, which might affect the gene's function. In the COPD GWAS, rs17486278 is associated with a higher risk for COPD.

The CHRNA5 gene has been shown to regulate nicotine addiction. Besides being highly conserved, CHRNA5 also serves other important functions in humans. It is believed that CHRNA5 evolved to fulfill these functions long before cigarette smoking was widely adopted. Although its role in nicotine addiction remains unclear, it is thought that CHRNA5 has multiple functions that may influence the addictive nature of nicotine. Therefore, it is important to understand whether CHRNA5 plays any role in the nicotine addiction process.