CHRNA5 Antibodies

AND CHRNA5 ELISA kits, CHRNA5 Proteins

Many biological assays use antibodies to detect CHRNA5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHRNA5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHRNA5 antibodies...

We validate the specificity of these antibodies to CHRNA5 by testing them on tissues known to express CHRNA5 positively and negatively. Browse below to find the CHRNA5 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CHRNA5 Infographic by Boster Bio

All CHRNA5 Products

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Product

Figures

Specificity

Applications

Price

Anti-Nicotinic Acetylcholine Receptor alpha 5/CHRNA5 Antibody Picoband®

5 Citations 5 Q&As

Human, Mouse, Rat

Flow Cytometry, IHC, ICC, WB

$370
Cat # A02359-2
100 μg/vial

Anti-CHRNA5 Mouse Monoclonal Antibody [Clone ID: OTI8H10]

Human, Mouse, Rat

$523
Cat # M02359
100 µl

Anti-CHRNA5 Rabbit Monoclonal Antibody

1 Citations

Human, Mouse, Rat

Flow Cytometry, IP, WB

$370
Cat # M02359-1
100 μl/vial

CHRNA5 Overview

Facts about Neuronal acetylcholine receptor subunit alpha-5.

CHRNA5 3D structure. Source: alphafold

Neuronal acetylcholine receptor subunit alpha-5 (CHRNA5)

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. .

Gene Information

Human
Gene Name:	CHRNA5
Uniprot:	P30532
Entrez:	1138

Family

Belongs to:

ligand-gated ion channel (TC 1.A.9) family

Alternative Names

Cholinergic receptor, neuronal nicotinic, alpha polypeptide-5; cholinergic receptor, nicotinic, alpha 5; cholinergic receptor, nicotinic, alpha polypeptide 5; CHRNA5; LNCR2; NACHRA5; neuronal acetylcholine receptor subunit alpha-5; neuronal nicotinic acetylcholine receptor, alpha5 subunit; Nicotinic Acetylcholine R alpha 5; Nicotinic Acetylcholine Ra5

Molecular Weight

Mass (kDA):
53.054 kDA

Genomic Context


Human

Location:	15q25.1
Sequence:	15; NC_000015.10 (78565520..78595269)

Subcellular Localizations

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Diseases

Nicotine Dependence
Tobacco Use Disorder
Malignant Neoplasms
Malignant Neoplasm Of Lung
Lung Neoplasms
Dysequilibrium Syndrome
Chronic Obstructive Airway Disease
Lung Diseases
Lung Diseases, Obstructive
Adenocarcinoma
Epilepsy

Epilepsy, Frontal Lobe
Cholangiocarcinoma
Substance-related Disorders
Non-small Cell Lung Carcinoma
Malignant Squamous Cell Neoplasm
Pulmonary Emphysema

Interacting Proteins

CHRNB2

Pathways

Pathogenesis
Localization
Chromosome Localization
Cell Proliferation
Cognition
Response To Nicotine
Cell Adhesion
Habituation
Prepulse Inhibition
Catecholamine Secretion
Fertilization
Aging
Cellular Response To Nicotine

Response To Alcohol
Startle Response
Methylation
Sensitization
Cell Cycle
Acrosome Reaction
Cell Growth

PTMs

Phosphorylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHRNA5

References

PMID: 1542648 by Chini B., et al. Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines.

PMID: 8906617 by Elliott K.J., et al. Comparative structure of human neuronal alpha 2-alpha 7 and beta 2- beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.

6 Publications of Boster CHRNA5 Antibodies & ELISA Kits

PubMed ID: 10.3390/md18010061, Differential Expression of Nicotine Acetylcholine Receptors Associates with Huma...
PubMed ID: 10.3390/md17050256, Cervical Cancer Correlates with the Differential Expression of Nicotinic Acetylc...
PubMed ID: 10.1016/j.freeradbiomed.2021.01.047, Transgenic expression of SOD1 specifically in neurons of Sod1 deficient mice pre...
PubMed ID: 10.1016/j.ejphar.2019.172674, Identification of nicotinic acetylcholine receptor subunits in different lung ca...
PubMed ID: 33561489, Su Y,Ahn B,Macpherson PCD,Ranjit R,Claflin DR,Van Remmen H,Brooks SV.Transgenic ...
PubMed ID: 31963558, Sun Z,Zhangsun M,Dong S,Liu Y,Qian J,Zhangsun D,Luo S.Differential Expression of...

*More publications can be found for each product on its corresponding product page