CHRNA1 Antibodies

AND CHRNA1 ELISA kits, CHRNA1 Proteins

Many biological assays use antibodies to detect CHRNA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHRNA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHRNA1 antibodies...

We validate the specificity of these antibodies to CHRNA1 by testing them on tissues known to express CHRNA1 positively and negatively. Browse below to find the CHRNA1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CHRNA1 Infographic by Boster Bio

All CHRNA1 Products

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Product

Figures

Specificity

Applications

Price

Anti-Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody Picoband®

1 Citations 1 Q&As

Human, Mouse, Rat

$370
Cat # PA1203
100 μg/vial

Anti-AChR Alpha 1 (E217) CHRNA1 Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A03723
100ul

CHRNA1 (NM_001039523) Human Over-expression Lysate

Human

$960
Cat # LS001134
100 µg

CHRNA1 Overview

Facts about Acetylcholine receptor subunit alpha.

CHRNA1 3D structure. Source: alphafold

Acetylcholine receptor subunit alpha (CHRNA1)

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. .

Gene Information

Human
Gene Name:	CHRNA1
Uniprot:	P02708
Entrez:	1134

Family

Belongs to:

ligand-gated ion channel (TC 1.A.9) family

Alternative Names

acetylcholine receptor subunit alpha; ACHRA; ACHRD; CHNRA; cholinergic receptor, nicotinic, alpha 1 (muscle); CHRNA; CHRNA1; CMS2A; FCCMS; nAChR alpha 1; nAchRa1; Nicotinic Acetylcholine R alpha 1 ; Nicotinic Acetylcholine Ra1 ; nicotinic acetylcholine receptor alpha subunit; nicotinic cholinergic receptor alpha 1; nicotinic, alpha polypeptide 1 (muscle); SCCMS

Molecular Weight

Mass (kDA):
54.546 kDA

Genomic Context


Human

Location:	2q31.1
Sequence:	2; NC_000002.12 (174747592..174764472, complement)

Tissue Specificity

Isoform 1 is only expressed in skeletal muscle. Isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus.

Subcellular Localizations

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Diseases

Myasthenias
Myasthenic Syndromes, Congenital
Myasthenia Gravis
Pterygium
Pena-shokeir Syndrome Type I
Autoimmune Reaction
Autoimmunity
Myopathy
Malignant Neoplasms
Malignant Neoplasm Of Lung
Multiple Pterygium Syndrome

Hydrops Fetalis
Tobacco Use Disorder
Dysequilibrium Syndrome
Fetal Diseases
Autoimmune Diseases
Nicotine Dependence

Pathways

Translation
Pathogenesis
Localization
Reverse Transcription
Gene Silencing
Cell Development
Muscle Contraction
Response To Nicotine

Innervation
Somite Development
Regulation Of Blood Pressure

PTMs

Phosphorylation

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHRNA1

References

PMID: 6688857 by Noda M., et al. Cloning and sequence analysis of calf cDNA and human genomic DNA encoding alpha-subunit precursor of muscle acetylcholine receptor.

PMID: 3338555 by Schoepfer R., et al. The human medulloblastoma cell line TE671 expresses a muscle-like acetylcholine receptor. Cloning of the alpha-subunit cDNA.

1 Publications of Boster CHRNA1 Antibodies & ELISA Kits

PubMed ID: 33561489, Su Y,Ahn B,Macpherson PCD,Ranjit R,Claflin DR,Van Remmen H,Brooks SV.Transgenic ...

*More publications can be found for each product on its corresponding product page