CHP2 Antibodies

AND CHP2 ELISA kits, CHP2 Proteins

Many biological assays use antibodies to detect CHP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHP2 antibodies...

We validate the specificity of these antibodies to CHP2 by testing them on tissues known to express CHP2 positively and negatively. Browse below to find the CHP2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CHP2 Infographic by Boster Bio

All CHP2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-CHP2 Antibody

3 Q&As

Human, Mouse, Rat

$360
Cat # A08478
100 µl

Anti-CHP2 Antibody

Human, Mouse, Rat

ICC, WB

$405
Cat # A08478-1
100ul

CHP2 (NM_022097) Human Over-expression Lysate

Human

$628
Cat # LS063928
100 µg

CHP2 Overview

Facts about Calcineurin B homologous protein 2.

CHP2 3D structure. Source: alphafold

Calcineurin B homologous protein 2 (CHP2)

Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent fashion, thus increasing pH and protecting cells from serum deprivation- induced death.

Also plays a role in the regulation of cell proliferation and tumor growth by raising the phosphatase activity of PPP3CA at a calcium-dependent method. Activator of this calcineurin/NFAT signaling pathway.

Gene Information

Human
Gene Name:	CHP2
Uniprot:	O43745
Entrez:	63928

Family

Belongs to:

calcineurin regulatory subunit family

Alternative Names

Calcineurin B homologous protein 2

Molecular Weight

Mass (kDA):
22.452 kDA

Genomic Context


Human

Location:	16p12.2
Sequence:	16; NC_000016.10 (23755026..23758935)

Tissue Specificity

Expressed in malignantly transformed cells but not detected in normal tissues.

Subcellular Localizations

Nucleus. Cytoplasm. Cell membrane. Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm.

PTMs

Lipoprotein

Myristate

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHP2

References

PMID: 12097419 by Wang Y., et al. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies.

PMID: 12226101 by Pang T., et al. Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger.