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- Table of Contents
1 Citations 16 Q&As
1 Citations 5 Q&As
Facts about Cofilin-1.
Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization.
Human | |
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Gene Name: | CFL1 |
Uniprot: | P23528 |
Entrez: | 1072 |
Belongs to: |
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actin-binding proteins ADF family |
18 kDa phosphoprotein; CFL; cofilin 1 (non-muscle); Cofilin, non-muscle isoform; cofilin-1; p18
Mass (kDA):
18.502 kDA
Human | |
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Location: | 11q13.1 |
Sequence: | 11; NC_000011.10 (65854673..65858180, complement) |
Widely distributed in various tissues.
Nucleus matrix. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
PMID: 2263493 by Ogawa K., et al. Coding sequence of human placenta cofilin cDNA.
PMID: 7552146 by van der Steege G., et al. A provisional transcript map of the spinal muscular atrophy (SMA) critical region.
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