Ceramide synthase 4 Antibodies

Ceramide synthase 4 (Cers4)

May be either a bona fide (dihydro)ceramide synthase or a modulator of its action. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner.

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Gene Information

Mouse
Gene Name:	Cers4
Uniprot:	Q9D6J1
Entrez:	67260

Family

Belongs to:
No superfamily

Alternative Names

CerS4; FLJ12089; LAG1 homolog, ceramide synthase 4; LAG1 longevity assurance homolog 4 (S. cerevisiae); LAG1 longevity assurance homolog 4; Trh1

Molecular Weight

Mass (kDA):
46.017 kDA

Genomic Context

Mouse
Location:	8|8 A1.1
Sequence:	8;

Diseases

• Malignant Neoplasms
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Adenocarcinoma
• Breast Adenocarcinoma
• Colonic Neoplasms
• Malignant Tumor Of Colon
• Endoplasmic Reticulum Stress

• Neoplasms
• Ductal Carcinoma
• Dysequilibrium Syndrome

Pathways

• Senescence
• Cell Proliferation
• Induction Of Apoptosis
• Cell Growth
• Myelination

PTMs

• Glycoprotein

• Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Cers4

Best Uses Of The CERS4 Marker

This article will provide information about Steven Boster's career and life. It will cover his research and products as well as his career. You will also learn about Boster's high-affinity primary antibodies. These antibodies are trusted by the research community, and are validated for use in Western Blotting, Immunohistochemistry, and ELISA.

His career

His career with the CERS4 marker was born out of his interest in liver cancers, and the gene itself. CERS4 could be a candidate marker to detect HCC. CERS4 plays a crucial role in liver tumour development and could lead towards more targeted treatments. The gene is also highly conserved among different types of tumors, so it could be useful for precision medicine. Scientists must first identify whether the CERS4 gene has been found in cancerous tissue.

His research

His research on CERS4 focuses on the role ceramide plays in the structure of the biological cell membrane. This important molecule is involved cellular processes like cell growth, proliferation, differentiation and motility. This hypothesis is further supported with the role of CERS4 for HCC cell proliferation. More research is needed to determine how this protein affects cellular processes. This gene is not yet widely studied.

Interestingly, his work has also led to a new way to treat liver cancer. He demonstrated that liver cancer cells can be suppressed by silencing the CERS4 genes. CERS4 knockdown also stopped the cell cycle, which in turn slows down cell growth. In this way, CERS4 may play an important role in the regulation of liver cancer cells. Scientists and doctors can be encouraged by his findings.