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Ceramide synthase 3 Antibodies

AND CERS3 ELISA kits, Ceramide synthase 3 Proteins

Many biological assays use antibodies to detect Ceramide synthase 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ceramide synthase 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ceramide synthase 3 antibodies...

We validate the specificity of these antibodies to Ceramide synthase 3 by testing them on tissues known to express CERS3 positively and negatively. Browse below to find the CERS3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CERS3 Infographic by Boster Bio

CERS3 protein infographic

All CERS3 Products

Product

Figures

Specificity

Applications

Price

LASS3 (CERS3) (NM_178842) Human Recombinant Protein

$1249
Cat # PROTQ8IU89
20 µg

LASS3 (CERS3) (NM_178842) Human Over-expression Lysate

Human

$628
Cat # LS204219
100 µg

CERS3 Overview

Facts about Ceramide synthase 3.

CERS3 3D structure

CERS3 3D structure. Source: alphafold

Ceramide synthase 3 (CERS3)

Has (dihydro)ceramide synthesis activity with relatively broad substrate specificity, but a taste for C18:0 and other middle- to long-chain fatty acyl-CoAs (By similarity). It is a must for the synthesis of very long-chain ceramides from the skin, to maintain epidermal lipid homeostasis and terminal differentiation.

.

Gene Information

Human
Gene Name:	CERS3
Uniprot:	Q8IU89
Entrez:	204219

Gene Information

Family

Belongs to:

No superfamily

Family

Alternative Names

CerS3; LAG1 homolog, ceramide synthase 3; LAG1 longevity assurance homolog 3 (S. cerevisiae); LAG1 longevity assurance homolog 3; MGC27091

Molecular Weight

Mass (kDA):
46.316 kDA

Molecular Weight

Genomic Context


Human

Location:	15q26.3
Sequence:	15; NC_000015.10 (100400395..100544982, complement)

Tissue Specificity

Expressed in the epidermis, where it localizes at the interface between the stratum granulosum and the stratum corneum (at protein level).

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular Localization

Diseases

Lymphoma
Barrett Esophagus
Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse
Growth Arrest
Infection By Candida Albicans
Hyperkeratosis

Disease

Pathways

Cornification
Cell Death
Glycosylation
Cell Growth
Pachytene
Meiosis
Spermatogenesis

Fucosylation
Cytokinesis

Pathways

PTMs

Phosphoprotein

Bosterbio | ELISA Kits, Antibodies, Antibody Company

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CERS3

References

PMID: 17977534 by Lahiri S., et al. Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.

PMID: 22038835 by Jennemann R., et al. Loss of ceramide synthase 3 causes lethal skin barrier disruption.