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CEP55 Antibodies
AND CEP55 ELISA kits, CEP55 Proteins
Many biological assays use antibodies to detect CEP55, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CEP55 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CEP55 antibodies...
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CEP55 Overview
Facts about Centrosomal protein of 55 kDa.
Centrosomal protein of 55 kDa (CEP55)
Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis.
Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290).
Gene Information
| Human | |
|---|---|
| Gene Name: | CEP55 |
| Uniprot: | Q53EZ4 |
| Entrez: | 55165 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
C10orf3; cancer/testis antigen 111; centrosomal protein 55kDa; centrosomal protein of 55 kDa; Cep55; chromosome 10 open reading frame 3; CT111; FLJ10540; Up-regulated in colon cancer 6; URCC6
Molecular Weight
Mass (kDA):
54.178 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q23.33 |
| Sequence: | 10; NC_000010.11 (93496612..93529094) |
Tissue Specificity
Expressed in embryonic brain (PubMed:28264986). Expressed in fetal brain ganglionic eminence, kidney tubules and multinucleate neurons in the temporal cortex (PubMed:28264986). Expressed in adult brain, cerebellum, kidney tubules, intestine and muscles (at protein level) (PubMed:28295209, PubMed:28264986). Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate levels in adult and fetal thymus, as well as in various cancer cell lines. Low levels in different parts of the digestive tract, bone marrow, lymph nodes, placenta, fetal heart and fetal spleen. Hardly detected in brain.
Subcellular Localizations
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody, Midbody ring. Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loses affinity for the centrosome at the onset of prophase and diffuses throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mi
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Neoplasm Metastasis
- Malignant Squamous Cell Neoplasm
- Malignant Neoplasm Of Breast
- Neoplasm Invasiveness
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Lung
- Cell Invasion
- Mammary Neoplasms
Interacting Proteins
- ANXA11
- ARHGEF15
- C1orf109
- CCBE1
- CDC45
- CEP57L1
- DTNB
- EIF1AD
- FAM90A1
- FXR2
Pathways
- Cytokinesis
- Abscission
- Transport
- Cell Division
- Cell Cycle
- Mitosis
- Localization
- Cell Migration
- Anaphase
- Membrane Fission
- Interphase
- Cell Growth
- Cleavage Furrow Ingression
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CEP55
bosterbio.com/bosterbio-gene-info-cards/CEP55
References
PMID: 16406728 by Martinez-Garay I., et al. The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody.
PMID: 16198290 by Fabbro M., et al. Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis.