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Centromere protein J Antibodies
AND CENPJ ELISA kits, Centromere protein J Proteins
Many biological assays use antibodies to detect Centromere protein J, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Centromere protein J in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Centromere protein J antibodies...
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CENPJ Overview
Facts about Centromere protein J.
Centromere protein J (CENPJ)
Plays an important role in cell division and centrosome function by engaging in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome.
Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end monitoring protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and expansion from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797).
Gene Information
| Human | |
|---|---|
| Gene Name: | CENPJ |
| Uniprot: | Q9HC77 |
| Entrez: | 55835 |
Family
| Belongs to: |
|---|
| TCP10 family |
Alternative Names
BM032; CENP-J; centromere protein J; Centrosomal P4.1-associated protein; CPAPMCPH6; LAG-3-associated protein; LAPSCKL4; LIP1microcephaly, primary autosomal recessive 6; LYST-interacting protein 1; LYST-interacting protein LIP1; LYST-interacting protein LIP7; MGC131581; MGC131582; MGC142222; MGC142224; Sas-4; SASS4
Molecular Weight
Mass (kDA):
153 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q12.12-q12.13 |
| Sequence: | 13; NC_000013.11 (24882279..24922889, complement) |
Subcellular Localizations
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Localized within the center of microtubule asters (PubMed:11003675). During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles (PubMed:17681131).
Diseases
- Microcephaly
- Primary Microcephaly
- Dwarfism
- Seckel Syndrome
- Hereditary Diseases
- Dysplasia
- Malignant Neoplasms
- Genomic Instability
- Inflammation
- Bronchopulmonary Dysplasia
- Malignant Neoplasm Of Breast
Interacting Proteins
- CEP135
- CIC
- GFI1B
- PLK2
- STIL
- TNKS
- YWHAG
Pathways
- Cell Cycle
- Mitosis
- Cell Division
- Centrosome Duplication
- Neurogenesis
- Brain Development
- Microtubule Nucleation
- Localization
- Centriole Replication
- Cytokinesis
- Spindle Assembly
- Cell Death
- Pathogenesis
PTMs
- Phosphorylation
Research Areas
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CENPJ
bosterbio.com/bosterbio-gene-info-cards/CENPJ
References
PMID: 11003675 by Hung L.-Y., et al. Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated with the gamma-tubulin complex.
PMID: 11984006 by Tchernev V.T., et al. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.