Centromere protein N Antibodies

AND CENPN ELISA kits, Centromere protein N Proteins

Many biological assays use antibodies to detect Centromere protein N, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Centromere protein N in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Centromere protein N antibodies...

We validate the specificity of these antibodies to Centromere protein N by testing them on tissues known to express CENPN positively and negatively. Browse below to find the CENPN antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CENPN Infographic by Boster Bio

All CENPN Products

Product

Figures

Specificity

Applications

Price

Anti-Centromere protein N CENPN Antibody

Human

ELISA, WB

$380
Cat # A09116
100ul

CENPN (NM_001100625) Human Over-expression Lysate

Human

$628
Cat # LS055839
100 µg

CENPN Overview

Facts about Centromere protein N.

CENPN 3D structure. Source: alphafold

Centromere protein N (CENPN)

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and can be involved in incorporation of newly synthesized CENPA into centromeres.

CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is necessary for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.

Gene Information

Human
Gene Name:	CENPN
Uniprot:	Q96H22
Entrez:	55839

Family

Belongs to:

CENP-N/CHL4 family

Alternative Names

BM039; C16orf60; CENP-N; centromere protein N; chromosome 16 open reading frame 60; FLJ13607; FLJ22660; ICEN32; Interphase centromere complex protein 32

Molecular Weight

Mass (kDA):
39.555 kDA

Genomic Context


Human

Location:	16q23.2
Sequence:	16; NC_000016.10 (81006498..81033107)

Subcellular Localizations

Nucleus. Chromosome, centromere, kinetochore. Localizes exclusively in the kinetochore domain of centromeres. Kinetochore-bound levels decrease when cells enter mitosis and increase again when cells exit mitosis.

PTMs

Phosphoprotein

Research Areas

Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CENPN

References

PMID: 16716197 by Izuta H., et al. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells.

PMID: 16622420 by Okada M., et al. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.