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- Table of Contents
Facts about CUGBP Elav-like family member 5.
Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternate exon 5 of TNNT2 pre-mRNA.
Human | |
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Gene Name: | CELF5 |
Uniprot: | Q8N6W0 |
Entrez: | 60680 |
Belongs to: |
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CELF/BRUNOL family |
Bruno (Drosophila) -like 5, RNA binding protein; BRUNOL-5; BRUNOL5bruno-like 5, RNA binding protein (Drosophila); bruno-like 5 RNA binding protein; Bruno-like protein 5; CELF-5; CUG-BP and ETR-3 like factor 5; CUG-BP- and ETR-3-like factor 5; CUGBP Elav-like family member 5; CUGBP, Elav-like family member 5; RNA-binding protein BRUNOL-5
Mass (kDA):
52.355 kDA
Human | |
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Location: | 19p13.3 |
Sequence: | 19; NC_000019.10 (3224661..3297076) |
Expressed in brain.
Nucleus. Cytoplasm.
PMID: 11158314 by Ladd A.N., et al. The CELF family of RNA binding proteins is implicated in cell- specific and developmentally regulated alternative splicing.
PMID: 10893231 by Good P.J., et al. A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator.