CELF4 Antibodies

AND CELF4 ELISA kits, CELF4 Proteins

Many biological assays use antibodies to detect CELF4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CELF4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CELF4 antibodies...

We validate the specificity of these antibodies to CELF4 by testing them on tissues known to express CELF4 positively and negatively. Browse below to find the CELF4 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CELF4 Infographic by Boster Bio

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CELF4 Overview

Facts about CUGBP Elav-like family member 4.

CELF4 3D structure. Source: alphafold

CUGBP Elav-like family member 4 (CELF4)

RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing.

Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs.

Gene Information

Human
Gene Name:	CELF4
Uniprot:	Q9BZC1
Entrez:	56853

Family

Belongs to:

CELF/BRUNOL family

Alternative Names

Bruno (Drosophila) -like 4, RNA binding protein; BRUNOL-4; BRUNOL4Bruno -like 4, RNA binding protein; bruno-like 4, RNA binding protein (Drosophila); bruno-like 4, RNA binding protein; Bruno-like protein 4; CELF-4; CUG-BP and ETR-3 like factor 4; CUG-BP- and ETR-3-like factor 4; CUGBP Elav-like family member 4; CUGBP, Elav-like family member 4; LYST-interacting protein LIP9; RNA-binding protein BRUNOL4; RNA-binding protein BRUNOL-4

Molecular Weight

Mass (kDA):
51.966 kDA

Genomic Context


Human

Location:	18q12.2
Sequence:	18; NC_000018.10 (37243040..37565798, complement)

Tissue Specificity

Ubiquitous. Strongly expressed in the cerebellum, hippocampus, amygdala, temporal and frontal cortex and frontal lobes.

Subcellular Localizations

Nucleus. Cytoplasm.

Diseases

Myotonic Dystrophy
Dystrophy
Epilepsy
Nervous System Disorder
Infarction
Neurodegenerative Disorders
Cardiac Hypertrophy
Torsades De Pointes
Fibrosis
Myocardial Infarction
Nervousness
Febrile Convulsions

Eye Manifestations
Neuroblastoma
Convulsive Seizures
Hereditary Diseases
Long Qt Syndrome
Channelopathies

Pathways

Heart Development
Transport
Response To Iloperidone
Translation
Mrna Stabilization
Brain Development
Neurogenesis
Synaptic Transmission

Neuron Development
Rna Processing
Regulation Of Synaptic Plasticity

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CELF4

References

PMID: 11158314 by Ladd A.N., et al. The CELF family of RNA binding proteins is implicated in cell- specific and developmentally regulated alternative splicing.

PMID: 10893231 by Good P.J., et al. A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator.