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- Table of Contents
Facts about CDK5 regulatory subunit-associated protein 3.
Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may cause MDM2- dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation.
Rat | |
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Gene Name: | Cdk5rap3 |
Uniprot: | Q9JLH7 |
Entrez: | 80278 |
Belongs to: |
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CDK5RAP3 family |
C53; CDK5 activator-binding protein C53; CDK5 regulatory subunit associated protein 3; FLJ13660; HSF-27; IC53CDK5 regulatory subunit-associated protein 3; ischemic heart CDK5 activator-binding protein C53; LXXLL/leucine-zipper-containing ARFbinding protein; LZAP; MST016; OK/SW-cl.114; Protein HSF-27
Mass (kDA):
57.045 kDA
Rat | |
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Location: | 10q31 |
Sequence: | 10; |
Expressed in vascular endothelium. Up- regulated in failing heart. Highly expressed in the ventricular section in subacute and chronic ischemic heart failure.
PMID: 10721722 by Ching Y.-P., et al. Cloning of three novel neuronal Cdk5 activator binding proteins.
PMID: 12054757 by Chen J., et al. A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart.