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Cyclin-dependent kinase 2 Antibodies
AND CDK2 ELISA kits, Cyclin-dependent kinase 2 Proteins
Many biological assays use antibodies to detect Cyclin-dependent kinase 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cyclin-dependent kinase 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cyclin-dependent kinase 2 antibodies...
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CDK2 Infographic by Boster Bio
All CDK2 Products
Product
Figures
Specificity
Applications
Price
Anti-Cyclin-dependent kinase 2 Cdk2 Antibody Picoband®
15 Citations 4 Q&As
Human, Mouse, Rat
WB
$370
Cat # PA1547
100 μg/vial
Cat # PA1547
100 μg/vial
Anti-Cyclin-dependent kinase 2 cdk2 Antibody
5 Citations 15 Q&As
Human, Mouse, Rat
IHC, WB
$629
Cat # A00166
100uL
Cat # A00166
100uL
Anti-CDK2 Rabbit Monoclonal Antibody
5 Citations 17 Q&As
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M00166
100 μl
Cat # M00166
100 μl
Anti-Phospho-CDK2 (Y15) Rabbit Monoclonal Antibody
5 Citations 15 Q&As
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # MP00166
100 μl
Cat # MP00166
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1108
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1108
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC1968
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1968
1 kit, containing two 96-well plates and all necessary reagents
Human, Monkey, Mouse, Rat
ELISA, IF, WB
$380
Cat # A00166T14
100ul
Cat # A00166T14
100ul
Dog, Human, Monkey, Mouse, Rat
Flow Cytometry, IF, WB
$523
Cat # M00166-2
100 µl
Cat # M00166-2
100 µl
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M00166-3
100 μg/vial
Cat # M00166-3
100 μg/vial
Anti-Cdk2 Antibody Picoband® (monoclonal, 6D5B5)
5 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # M00166-4
100 μg/vial
Cat # M00166-4
100 μg/vial
CDK2 Overview
Facts about Cyclin-dependent kinase 2.
Cyclin-dependent kinase 2 (CDK2)
Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Triggers duplication of centrosomes and DNA.
Acts in the G1-S transition to advertise the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 development; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 in the centrosome and in the nucleus. Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the first stages of DNA synthesis to allow G1-S transition, and then activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to induce the transition from S phase to mitosis, the G2 phase.
Gene Information
| Human | |
|---|---|
| Gene Name: | CDK2 |
| Uniprot: | P24941 |
| Entrez: | 1017 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
cdc2-related protein kinase; CDK2; cell devision kinase 2; Cell division protein kinase 2; cyclin-dependent kinase 2; EC 2.7.11; EC 2.7.11.22; p33 protein kinase; p33(CDK2)
Molecular Weight
Mass (kDA):
33.93 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.2 |
| Sequence: | 12; NC_000012.12 (55966830..55972789) |
Subcellular Localizations
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, Cajal body. Cytoplasm. Endosome. Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25-(OH)(2)D(3).
Diseases
- Malignant Neoplasms
- Neoplasms
- Retinoblastoma
- Carcinoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Growth Arrest
- Hyperplasia
- Leukemia
- Malignant Paraganglionic Neoplasm
- Prostatic Neoplasms
Interacting Proteins
- CCNA2
- Ccna2
- CCNB2
- CCND1
- CCNE1
- CCNE2
- CCNH
- CDK7
- CDKN1A
- CDKN1B
Pathways
- Cell Cycle
- Cell Proliferation
- S Phase
- Cell Cycle Arrest
- Cell Growth
- G1 Phase
- Dna Replication
- Cell Death
- Mitosis
- Localization
- Cell Division
- Induction Of Apoptosis
- Hyperphosphorylation
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Ubiquitination
- Acetylation
- Methylation
- Reduction
- Sumoylation
- Phosphorothioation
Research Areas
- Breast Cancer
- Cancer
- Cell Cycle and Replication
- Ovarian Carcinoma Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDK2
bosterbio.com/bosterbio-gene-info-cards/CDK2
References
PMID: 1714386 by Elledge S.J., et al. A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.
PMID: 1653904 by Tsai L.-H., et al. Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase.
29 Publications of Boster Cyclin-dependent kinase 2 Antibodies & ELISA Kits
- PubMed ID: 10.4161/15384101.2014.980631, Enterovirus 71 mediates cell cycle arrest in S phase through non-structural prot...
- PubMed ID: 10.3892/or.2016.4935, Platycodin D, a metabolite of Platycodin grandiflorum, inhibits highly metastati...
- PubMed ID: 10.3892/mmr.2016.5149, Effects of tripterygium glycosides on restenosis following endovascular treatmen...
- PubMed ID: 10.1248/bpb.30.2274, Chemically Modified Heparin Inhibits Mesangial Cell Proliferation Induced by Hig...
- PubMed ID: 10.1080/07357900701788130, Suppression of C-myc Expression Associates with Anti-Proliferation of Aloe-Emodi...
- PubMed ID: 10.1038/aps.2016.34, Tubeimoside-1 induces oxidative stress-mediated apoptosis and G 0 /G 1 phase arr...
- PubMed ID: 10.1016/j.jgr.2021.06.002, The anti-tumor efficacy of 20(S)-protopanaxadiol, an active metabolite of ginsen...
- PubMed ID: 10.1016/j.archoralbio.2016.08.002, 2,3,7,8-Tetrachlorodibenzo-p-dioxin Mediated Cleft palate by Mouse Embryonic Pal...
- PubMed ID: 10.1007/s12032-009-9415-5, Anticancer effect of Lycium barbarum polysaccharides on colon cancer cells invol...
- PubMed ID: 10.1007/s12032-009-9286-9, Growth inhibition and cell-cycle arrest of human gastric cancer cells by Lycium ...
- PubMed ID: 10.1002/ptr.5182, Growth Inhibition Effects of Isoalantolactone on K562/A02 Cells: Caspase‐depen...
- PubMed ID: 10.1002/jcb.25994, Dehydrocostus Lactone Suppresses Proliferation of Human Chronic Myeloid Leukemia...
- PubMed ID: 10.1002/cbin.10892, OAMDP, a novel podophyllotoxin derivative, induces apoptosis, cell cycle arrest ...
- PubMed ID: -, Wenzhen Li,Yifan Wang,Xinbo Zhou,Xiaohong Pan,Junhong Lü,Hongliu Sun,Zeping Xie...
- PubMed ID: 30340635, IL-2R%u03B1 up-regulation is mediated by latent membrane protein 1 and promotes ...
- PubMed ID: 27432230, Platycodin D, a metabolite of Platycodin grandiflorum, inhibits highly metastati...
- PubMed ID: 27292614, Tubeimoside-1 induces oxidative stress-mediated apoptosis and G0/G1 phase arrest...
- PubMed ID: 25659038, Enterovirus 71 mediates cell cycle arrest in S phase through non-structural prot...
- PubMed ID: 27840410, Rheum emodin inhibits enterovirus 71 viral replication and affects the host cell...
- PubMed ID: 27108914, Effects of tripterygium glycosides on restenosis following endovascular treatmen...
- PubMed ID: 27065079, TALENs-directed?knockout?of the?full-length?transcription?factor?Nrf1? that?repr...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page