CDC14B Antibodies

AND CDC14B ELISA kits, CDC14B Proteins

Many biological assays use antibodies to detect CDC14B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CDC14B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CDC14B antibodies...

We validate the specificity of these antibodies to CDC14B by testing them on tissues known to express CDC14B positively and negatively. Browse below to find the CDC14B antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CDC14B Infographic by Boster Bio

All CDC14B Products

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Specificity

Applications

Price

Anti-CC14B CDC14B Antibody

Human, Mouse

ELISA, WB

$380
Cat # A09661
100ul

CDC14B (NM_001077181) Human Over-expression Lysate

Human

$960
Cat # LS008555
100 µg

CDC14B Overview

Facts about Dual specificity protein phosphatase CDC14B.

CDC14B 3D structure. Source: alphafold

Dual specificity protein phosphatase CDC14B (CDC14B)

Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: subsequent DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C).

Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis.

Gene Information

Human
Gene Name:	CDC14B
Uniprot:	O60729
Entrez:	8555

Family

Belongs to:

protein-tyrosine phosphatase family

Alternative Names

CDC14 cell division cycle 14 homolog B (S. cerevisiae); CDC14 cell division cycle 14 homolog B; S. cerevisiae) homolog B

Molecular Weight

Mass (kDA):
56.802 kDA

Genomic Context


Human

Location:	9q22.32-q22.33
Sequence:	9; NC_000009.12 (96492743..96619843, complement)

Subcellular Localizations

Nucleus, nucleolus. Nucleus, nucleoplasm. Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1.

Diseases

Neoplasms
Genomic Instability
Genotoxic Stress
Carcinoma
Malignant Neoplasms
Epithelioma
Malignant Neoplasm Of Breast
Anaplastic Astrocytoma
Premature Aging Syndrome
Carcinoma, Papillary
Kidney Neoplasm
Hydrocephalus

Nervousness
Medulloblastoma
Radiation Induced Dna Damage
Cytogenetic Abnormality
Hyperdiploidy
Nervous System Neoplasms
Infective Disorder

Interacting Proteins

SIRT2

Pathways

Cell Cycle
Mitosis
Cytokinesis
Cell Division
Interphase
Localization
Exit From Mitosis
Anaphase
Dna Repair
Dna Replication
Chromosome Segregation
Centrosome Duplication
Aging

Nuclear Export
Dna Damage Checkpoint
Meiosis
Spindle Assembly
Cell Proliferation
Metaphase
Senescence

PTMs

Phosphorylation
Dephosphorylation
Methylation

Ubiquitination
Cleavage
Acetylation

Research Areas

Protein Phosphatase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDC14B

References

PMID: 9367992 by Li L., et al. A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast.

PMID: 12134069 by Kaiser B.K., et al. Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase.