This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Dual specificity protein phosphatase CDC14A.
Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis.
Human | |
---|---|
Gene Name: | CDC14A |
Uniprot: | Q9UNH5 |
Entrez: | 8556 |
Belongs to: |
---|
protein-tyrosine phosphatase family |
CDC14; CDC14A
Mass (kDA):
66.574 kDA
Human | |
---|---|
Location: | 1p21.2 |
Sequence: | 1; NC_000001.11 (100345001..100520281) |
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Cell projection, kinocilium. Cell projection, stereocilium. Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the mitotic spindle pole and at the central spindle (PubMed:12134069, PubMed:11901424, PubMed:15263015). Present along both the transient kinocilia of developing cochlear hair cells and the persistent kinocilia of vestibular hair cells (By similarity).
PMID: 9367992 by Li L., et al. A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast.
PMID: 10409437 by Wong A.K.C., et al. Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene.