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CD8A Antibodies
AND CD8A ELISA kits, CD8A Proteins
Many biological assays use antibodies to detect CD8A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CD8A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CD8A antibodies...
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CD8A Infographic by Boster Bio
All CD8A Products
Product
Figures
Specificity
Applications
Price
Anti-CD8 alpha/CD8A Antibody Picoband®
7 Citations 16 Q&As
Human
IHC, WB
$370
Cat # PB9249
100 μg/vial
Cat # PB9249
100 μg/vial
Anti-CD8 Cd8A Antibody (Monoclonal, CA-8)
5 Citations 2 Q&As
Human
Flow Cytometry, IHC, ICC
$370
Cat # MA1017
100 μg/vial
Cat # MA1017
100 μg/vial
Anti-human CD8 Cd8a Monoclonal Antibody APC Conjugated, Flow Validated
2 Citations 10 Q&As
Human
Flow Cytometry
$312
Cat # FC02236-APC
100 tests, 200 tests
Cat # FC02236-APC
100 tests, 200 tests
Anti-human CD8 Cd8a Monoclonal Antibody Biotin Conjugated, Flow Validated
2 Citations 3 Q&As
Human
Flow Cytometry
$226
Cat # FC02236-Biotin
100ug
Cat # FC02236-Biotin
100ug
Anti-human CD8 Cd8a Monoclonal Antibody FITC Conjugated, Flow Validated
2 Citations 11 Q&As
Human
Flow Cytometry
$208
Cat # FC02236-FITC
100 tests, 200 tests
Cat # FC02236-FITC
100 tests, 200 tests
Anti-human CD8 Cd8a Monoclonal Antibody PE Conjugated, Flow Validated
2 Citations 8 Q&As
Human
Flow Cytometry
$299
Cat # FC02236-PE
100 tests, 200 tests
Cat # FC02236-PE
100 tests, 200 tests
Anti-human CD8 Cd8a Monoclonal Antibody PerCP Conjugated, Flow Validated
2 Citations 10 Q&As
Human
Flow Cytometry
$338
Cat # FC02236-PerCP
100 tests, 200 tests
Cat # FC02236-PerCP
100 tests, 200 tests
Human
Flow Cytometry
$360
Cat # FC02236-PerCP-Cy5.5
100 tests, 200 tests
Cat # FC02236-PerCP-Cy5.5
100 tests, 200 tests
Anti-human CD8 Cd8a Monoclonal Antibody Unconjugated, Flow Validated
2 Citations 10 Q&As
Human
Flow Cytometry
$139
Cat # FC02236
100ug, 500ug
Cat # FC02236
100ug, 500ug
Anti-CD8 CD8A Rabbit Monoclonal Antibody
2 Citations 16 Q&As
Human, Rat
IF, IHC, ICC, WB
$370
Cat # M02236-1
100 μl
Cat # M02236-1
100 μl
Anti-CD8 alpha/Cd8a Antibody Picoband®
11 Citations 17 Q&As
Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A02236-1
100 μg/vial
Cat # A02236-1
100 μg/vial
Human
Flow Cytometry
$303
Cat # FC02236-mFluor540
100 tests, 200 tests
Cat # FC02236-mFluor540
100 tests, 200 tests
Anti-Mouse CD8 alpha DyLight® 488 conjugated Antibody
1 Citations 3 Q&As
Mouse
Flow Cytometry
$515
Cat # A02236-Dyl488
100 μg/vial
Cat # A02236-Dyl488
100 μg/vial
Anti-Mouse CD8 alpha DyLight® 550 conjugated Antibody
1 Citations 14 Q&As
Mouse
Flow Cytometry
$515
Cat # A02236-Dyl550
100 μg/vial
Cat # A02236-Dyl550
100 μg/vial
Anti-CD8 alpha/Cd8a Antibody Picoband®
1 Citations 4 Q&As
Rat
ELISA, IHC, WB
$370
Cat # A02236-2
100 μg/vial
Cat # A02236-2
100 μg/vial
Anti-Ms CD8a Purified Monoclonal Antibody
2 Citations
Mouse
Flow Cytometry, IP, IHC-P, IHC-F, ICC
$299
Cat # M02236
0.1 mg
Cat # M02236
0.1 mg
Anti-CD8 alpha/Cd8a Antibody Picoband®
4 Citations
Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A02236-3
100 μg/vial
Cat # A02236-3
100 μg/vial
CD8A Overview
Facts about T-cell surface glycoprotein CD8 alpha chain.
T-cell surface glycoprotein CD8 alpha chain (CD8A)
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins.
Interacts concurrently with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). Consequently, recruits the Src kinase LCK to the area of the TCR-CD3 complicated.
Gene Information
| Human | |
|---|---|
| Gene Name: | CD8A |
| Uniprot: | P01732 |
| Entrez: | 925 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
53-6.7 CD8 Alpha; 53-6.7 CD8 Aplha; 53-6.7 CD8; 53-6.7 Clone; 53-6.7; CD8; CD8; CD8a molecule; CD8A; Cytotoxic T cell marker; Cytotoxic T lymphocyte marker; LEU2; p32; T cell marker
Molecular Weight
Mass (kDA):
25.729 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p11.2 |
| Sequence: | 2; NC_000002.12 (86784605..86808396, complement) |
Tissue Specificity
CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homo-dimers. Expressed at the cell surface of plasmacytoid dendritic cells upon herpes simplex virus-1 stimulation.
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. CD8A localizes to lipid rafts only when associated with its partner CD8B.; [Isoform 2]: Secreted.
Diseases
- Neoplasms
- Malignant Neoplasms
- Chronic Lymphocytic Leukemia
- Rheumatoid Arthritis
- Virus Diseases
- Arthritis
- Leukemia
- Lymphoid Leukemia
- Malnutrition
- Infectious Mononucleosis
- Colonic Neoplasms
- Swine Diseases
- Malignant Tumor Of Colon
Pathways
- Immune Response
- Cell Development
- Chromatin Remodeling
- Cell Proliferation
- Mitosis
- Dna Methylation
- Regulation Of Gene Expression
- Localization
- Demethylation
- Methylation
PTMs
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD8A
bosterbio.com/bosterbio-gene-info-cards/CD8A
References
PMID: 3871356 by Littman D.R., et al. The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes.
PMID: 3936473 by Parnes J.R., et al. Structure of Leu-2/T8 as deduced from the sequence of a cDNA clone.
18 Publications of Boster CD8A Antibodies & ELISA Kits
- PubMed ID: PMID:31966704, MicroRNA-421 mediates immunosensitivity in late-stage human liver cancer
- PubMed ID: PMID:31966612, Clinical biocharacterization of immunophenotype in hepatocellular carcinoma pati...
- PubMed ID: 10.3389/fimmu.2021.616074, Berberine Prolongs Mouse Heart Allograft Survival by Activating T Cell Apoptosis...
- PubMed ID: 10.1177/1753425912456223, Effect of l-arginine on intestinal mucosal immune barrier function in weaned pig...
- PubMed ID: 10.1177/09636897211054503, Leflunomide Inhibits rat-to-Mouse Cardiac Xenograft Rejection by Suppressing Ada...
- PubMed ID: 10.1039/D1BM00726B, NO/ROS/RNS Cascaded-Releasing Nano-Platform for Gas/PDT/PTT/Immunotherapy of Tum...
- PubMed ID: 10.1016/j.fertnstert.2006.11.063, Endocrine function and lymphocyte infiltration of newborn rat ovaries after ultr...
- PubMed ID: 33889520, Liu Q,Hao Y,Du R,Hu D,Xie J,Zhang J,Deng G,Liang N,Tian T,Käsmann L,Rades D,Rim...
- PubMed ID: 32802195, Dai X,Lu L,Deng S,Meng J,Wan C,Huang J,Sun Y,Hu Y,Wu B,Wu G,Lovell JF,Jin H,Yang...
- PubMed ID: -, Jia-Hui Yan,Yi-Shun Ji,Man-Li Yang,Jun Fu,Hu Shan,Li−Li Wang,Lei Zhang,Jing-Yu...
- PubMed ID: 25308861, Myeloid differentiation factor 88 promotes cisplatin chemoresistance in ovarian ...
- PubMed ID: 15133849, Effect of Hejie decoction on T cell immune state of chronic hepatitis B patients
- PubMed ID: 25332128, Xu Q, Chen Y, Zhao Wm, Huang Zy, Duan Xj, Tong Yy, Zhang Y, Li X, Chang Gb, Chen...
- PubMed ID: 24038990, Zhao N, Li X, He X, Qiu Y, Zhu L, Qi F. J Gene Med. 2013 Oct;15(10):366-74. Doi:...
- PubMed ID: 25609949, Wang X, Shi L, Tu Q, Wang H, Zhang H, Wang P, Zhang L, Huang Z, Zhao F, Luan H, ...
- PubMed ID: 25816072, Xu Y, Tan X, Wang D, Wang W, Li Y, Wu M, Chen S, Wu Y, Tan C. Int J Mol Med. 201...
- PubMed ID: 25376933, Wu Y, Wang Y, Qi X, Zhang P, Zhang C, Zhang W. Nephron Exp Nephrol. 2014;128(1-2...
- PubMed ID: 20022135, Chen X, Wan J, Liu J, Xie W, Diao X, Xu J, Zhu B, Chen Z. Lung Cancer. 2010 Sep;...
*More publications can be found for each product on its corresponding product page