CD8B Antibodies

AND CD8B ELISA kits, CD8B Proteins

Many biological assays use antibodies to detect CD8B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CD8B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CD8B antibodies...

We validate the specificity of these antibodies to CD8B by testing them on tissues known to express CD8B positively and negatively. Browse below to find the CD8B antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CD8B Infographic by Boster Bio

All CD8B Products

Product

Figures

Specificity

Applications

Price

Anti-CD8B Antibody

Human, Mouse, Rat

$405
Cat # A07259
100ul

Human CD8 beta Recombinant Protein

SDS-PAGE

$250
Cat # PROTP10966
Starting from 4ug

CD8B (NM_172213) Human Over-expression Lysate

Human

$628
Cat # LS000926
100 µg

CD8B Overview

Facts about T-cell surface glycoprotein CD8 beta chain.

CD8B 3D structure. Source: alphafold

T-cell surface glycoprotein CD8 beta chain (CD8B)

Integral membrane glycoprotein which plays a vital role in the immune response and serves multiple roles in responses against both internal and external offenses. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins.

Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). Consequently, recruits the Src kinase LCK into the area of the TCR-CD3 complex.

Gene Information

Human
Gene Name:	CD8B
Uniprot:	P10966
Entrez:	926

Family

Belongs to:

No superfamily

Alternative Names

CD8 antigen, beta polypeptide 1 (p37); CD8 beta; CD8b antigen; CD8b molecule; CD8b; CD8B1; CD8B1P37; Leu2; LY3; LYT3; MGC119115; P37; T lymphocyte surface glycoprotein beta chain; T-cell surface glycoprotein CD8 beta chain

Molecular Weight

Mass (kDA):
23.722 kDA

Genomic Context


Human

Location:	2p11.2
Sequence:	2; NC_000002.12 (86815337..86861924, complement)

Tissue Specificity

Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells.

Subcellular Localizations

[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Requires the partner CD8A for efficient cell surface expression (PubMed:3145196). The heterodimer CD8A/CD8B localizes to lipid rafts due to CD8B cytoplasmic tail palmitoylation.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.; [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; [Isoform 5]: Cell membrane; Single-pass type I membrane protein.; [Isoform 6]: Secreted.; [Isoform 7]: Secreted.; [Isoform 8]: Secreted.