Leukocyte surface antigen CD47 (CD47)

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an essential role in memory formation and synaptic plasticity in the hippocampus (By similarity).

Receptor for SIRPA, binding to that prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.