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CD4 Antibodies
AND CD4 ELISA kits, CD4 Proteins
Many biological assays use antibodies to detect CD4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CD4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CD4 antibodies...
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CD4 Infographic by Boster Bio
All CD4 Products
Product
Figures
Specificity
Applications
Price
Anti-CD4 Antibody (Monoclonal, CA-4)
7 Citations 17 Q&As
Human
Flow Cytometry, IHC, ICC
$370
Cat # MA1016
100 μg/vial
Cat # MA1016
100 μg/vial
Cynomolgus monkey, Human, Rhesus monkey
Flow Cytometry
$226
Cat # FC00344-Biotin
100ug
Cat # FC00344-Biotin
100ug
Anti-human CD4 Monoclonal Antibody FITC Conjugated, Flow Validated
1 Citations 3 Q&As
Cynomolgus monkey, Human, Rhesus monkey
Flow Cytometry
$227
Cat # FC00344-FITC
100 tests, 200 tests
Cat # FC00344-FITC
100 tests, 200 tests
Anti-human CD4 Monoclonal Antibody PE Conjugated, Flow Validated
1 Citations 11 Q&As
Cynomolgus monkey, Human, Rhesus monkey
Flow Cytometry
$299
Cat # FC00344-PE
100 tests, 200 tests
Cat # FC00344-PE
100 tests, 200 tests
Cynomolgus monkey, Human, Rhesus monkey
Flow Cytometry
$312
Cat # FC00344-APC
100 tests, 200 tests
Cat # FC00344-APC
100 tests, 200 tests
Anti-human CD4 Monoclonal Antibody Unconjugated, Flow Validated
3 Citations 11 Q&As
Cynomolgus monkey, Human, Rhesus monkey
Flow Cytometry
$143
Cat # FC00344
100ug, 500ug
Cat # FC00344
100ug, 500ug
Cynomolgus monkey, Human, Rhesus monkey
Flow Cytometry
$360
Cat # FC00344-PerCP-Cy5.5
100 tests, 200 tests
Cat # FC00344-PerCP-Cy5.5
100 tests, 200 tests
Anti-CD4 Rabbit Monoclonal Antibody
1 Citations 4 Q&As
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00344
100 μl
Cat # M00344
100 μl
Cynomolgus monkey, Human, Rhesus monkey
Flow Cytometry
$303
Cat # FC00344-iFluor647
100 tests, 200 tests
Cat # FC00344-iFluor647
100 tests, 200 tests
Anti-Human CD4 Monoclonal Antibody mFluor450 Conjugated, Flow Validated
1 Citations 3 Q&As
Cynomolgus monkey, Human, Rhesus monkey
Flow Cytometry
$303
Cat # FC00344-mFluor450
100 tests, 200 tests
Cat # FC00344-mFluor450
100 tests, 200 tests
Anti-CD4 Rabbit Monoclonal Antibody, Clone#RM345
1 Citations 16 Q&As
Human
IHC, WB
$431
Cat # M00344-1
100uL
Cat # M00344-1
100uL
Human
Flow Cytometry, IP
$323
Cat # M00344-3
0.1 mg
Cat # M00344-3
0.1 mg
Anti-CD4 Antibody Picoband®
4 Citations 1 Q&As
Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00344-2
100 μg/vial
Cat # A00344-2
100 μg/vial
CD4 Overview
Facts about T-cell surface glycoprotein CD4.
T-cell surface glycoprotein CD4 (CD4)
Integral membrane glycoprotein which plays a vital role in the immune response and serves multiple functions in responses against both internal and external offenses. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins.
Interacts concurrently with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). Consequently, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complicated.
Gene Information
| Human | |
|---|---|
| Gene Name: | CD4 |
| Uniprot: | P01730 |
| Entrez: | 920 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD4 antigen (p55); CD4 antigen; CD4 molecule; CD4 receptor; CD4; CD4mut; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4
Molecular Weight
Mass (kDA):
51.111 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12p13.31 |
| Sequence: | 12; NC_000012.12 (6789528..6820810) |
Tissue Specificity
Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Diseases
- Hiv Infections
- Immunologic Deficiency Syndromes
- Acquired Immunodeficiency Syndrome
- Neoplasms
- Autoimmune Reaction
- Infective Disorder
- Inflammation
- Malignant Neoplasms
- Autoimmune Diseases
- Virus Diseases
- Decreased Immunologic Activity [pe]
- Aids-related Opportunistic Infections
Interacting Proteins
- CCR5
- LCK
- NR3C1
Pathways
- Immune Response
- Pathogenesis
- Secretion
- Cell Activation
- Cytokine Production
- Cell Proliferation
- T Cell Activation
- Cell Death
- Viral Replication
- T Cell Proliferation
- Hypersensitivity
- Cell Development
- Cell Differentiation
PTMs
- Phosphorylation
- Cleavage
- Glycosylation
- Methylation
- Acetylation
- Demethylation
- Reduction
- Dephosphorylation
- Ubiquitination
- Deglycosylation
Research Areas
- Adaptive Immunity
- Cell Biology
- Cellular Markers
- Cytokine Research
- Immunology
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD4
bosterbio.com/bosterbio-gene-info-cards/CD4
References
PMID: 2990730 by Maddon P.J., et al. The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.
PMID: 3263213 by Littman D.R., et al. Corrected CD4 sequence.
13 Publications of Boster CD4 Antibodies & ELISA Kits
- PubMed ID: 10.3389/fimmu.2021.616074, Berberine Prolongs Mouse Heart Allograft Survival by Activating T Cell Apoptosis...
- PubMed ID: 10.3109/00016489.2011.552525, High dose combination pertussis toxin induces autoimmune inner ear disease in Sp...
- PubMed ID: 10.1177/09636897211054503, Leflunomide Inhibits rat-to-Mouse Cardiac Xenograft Rejection by Suppressing Ada...
- PubMed ID: 10.1039/D1BM00726B, NO/ROS/RNS Cascaded-Releasing Nano-Platform for Gas/PDT/PTT/Immunotherapy of Tum...
- PubMed ID: 10.1038/s41385-018-0018-3, Colonic epithelial mTORC1 promotes ulcerative colitis through COX-2-mediated Th1...
- PubMed ID: 10.1016/j.fertnstert.2006.11.063, Endocrine function and lymphocyte infiltration of newborn rat ovaries after ultr...
- PubMed ID: 15133849, Effect of Hejie decoction on T cell immune state of chronic hepatitis B patients
- PubMed ID: 24038990, Zhao N, Li X, He X, Qiu Y, Zhu L, Qi F. J Gene Med. 2013 Oct;15(10):366-74. Doi:...
- PubMed ID: 25609949, Wang X, Shi L, Tu Q, Wang H, Zhang H, Wang P, Zhang L, Huang Z, Zhao F, Luan H, ...
- PubMed ID: 25816072, Xu Y, Tan X, Wang D, Wang W, Li Y, Wu M, Chen S, Wu Y, Tan C. Int J Mol Med. 201...
- PubMed ID: 25376933, Wu Y, Wang Y, Qi X, Zhang P, Zhang C, Zhang W. Nephron Exp Nephrol. 2014;128(1-2...
- PubMed ID: 20022135, Chen X, Wan J, Liu J, Xie W, Diao X, Xu J, Zhu B, Chen Z. Lung Cancer. 2010 Sep;...
- PubMed ID: 23308369, Ouyang W, An T, Guo D, Wu S, Tien P. Aids Res Hum Retroviruses. 2013 Mar;29(3):6...
*More publications can be found for each product on its corresponding product page