E3 ubiquitin-protein ligase CCNB1IP1 (CCNB1IP1)

Ubiquitin E3 ligase that acts as a limiting factor for crossing-over through meiosis: required through zygonema to restrict the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover websites. Later, it is guided by MutL- gamma to stably accumulate at designated crossover websites.

Probably promotes the dissociation of RNF212 and MutS-gamma to enable the progression of recombination and the implementation of the final measures of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase.