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GRHL3 Antibodies
AND GRHL3 ELISA kits, GRHL3 Proteins
Many biological assays use antibodies to detect GRHL3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GRHL3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GRHL3 antibodies...
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GRHL3 Overview
Facts about Grainyhead-like protein 3 homolog.
Grainyhead-like protein 3 homolog (GRHL3)
Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on different target genes (PubMed:21081122, PubMed:25347468).
Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as crucial direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the maturity, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury.
Gene Information
| Human | |
|---|---|
| Gene Name: | GRHL3 |
| Uniprot: | Q8TE85 |
| Entrez: | 57822 |
Family
| Belongs to: |
|---|
| grh/CP2 family |
Alternative Names
grainyhead-like 3 (Drosophila); MGC46624; Sister of mammalian grainyhead; sister-of-mammalian grainyhead; SOMTranscription factor CP2-like 4grainyhead-like protein 3 homolog; TFCP2L4; transcription factor hSOM1
Molecular Weight
Mass (kDA):
70.345 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.11 |
| Sequence: | 1; NC_000001.11 (24319333..24364482) |
Tissue Specificity
Expressed in brain, colon, pancreas, placenta and kidney. Isoform 1 is expressed in lung and tonsil. Isoform 2 is prostate-specific.
Subcellular Localizations
Nucleus.
Diseases
- Spina Bifida
- Exencephaly
- Congenital Abnormality
- Neoplasms
- Malignant Neoplasm Of Breast
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Malnutrition
- Carcinoma
- 5,10-methylenetetrahydrofolate Reductase Deficiency
- Folic Acid Deficiency
- Anencephaly
Interacting Proteins
- PRMT5
- PRMT6
Pathways
- Neural Tube Closure
- Tube Closure
- Wound Healing
- Cell Cycle
- Cell Migration
- Cell Proliferation
- Senescence
- Pathogenesis
- Cell Adhesion
- Cuticle Development
- Stem Cell Division
- Dorsal Closure
- Dna Repair
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRHL3
bosterbio.com/bosterbio-gene-info-cards/GRHL3
References
PMID: 12549979 by Ting S.B., et al. The identification and characterization of human sister-of-mammalian grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors.
PMID: 21081122 by Boglev Y., et al. The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity.