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- Table of Contents
Facts about Coiled-coil domain-containing protein 28B.
Involved in ciliogenesis.
Regulates cilia span through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complicated.Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not appear to modulate function and assembly of mTORC1 complex.
Mouse | |
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Gene Name: | Ccdc28b |
Uniprot: | Q8CEG5 |
Entrez: | 66264 |
Belongs to: |
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No superfamily |
coiled-coil domain containing 28B; coiled-coil domain-containing protein 28B; MGC1203; MGC16441; RP4-622L5.5
Mass (kDA):
22.033 kDA
Mouse | |
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Location: | 4|4 D2.2 |
Sequence: | 4; |
PMID: 16327777 by Badano J.L., et al. Dissection of epistasis in oligogenic Bardet-Biedl syndrome.
PMID: 23727834 by Cardenas-Rodriguez M., et al. The Bardet-Biedl syndrome-related protein CCDC28B modulates mTORC2 function and interacts with SIN1 to control cilia length independently of the mTOR complex.