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AGK Antibodies
AND AGK ELISA kits, AGK Proteins
Many biological assays use antibodies to detect AGK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AGK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AGK antibodies...
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AGK Overview
Facts about Acylglycerol kinase, mitochondrial.
Acylglycerol kinase, mitochondrial (AGK)
Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (PubMed:15939762). Doesn't phosphorylate sphingosine (PubMed:15939762).
Independently of its lipid kinase activity, acts as a part of the TIM22 complex (PubMed:28712724, PubMed:28712726). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins to the mitochondrial inner membrane by forming a twin-pore translocase which employs the membrane potential as the external driving force (PubMed:28712724, PubMed:28712726).
Gene Information
| Human | |
|---|---|
| Gene Name: | AGK |
| Uniprot: | Q53H12 |
| Entrez: | 55750 |
Family
| Belongs to: |
|---|
| AGK family |
Alternative Names
acylglycerol kinase; EC 2.7.1.107; EC 2.7.1.94; FLJ10842; hAGK; HsMuLK; mitochondrial; MuLK; MULKhsMuLK; Multi-substrate lipid kinase
Molecular Weight
Mass (kDA):
47.137 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q34 |
| Sequence: | 7; NC_000007.14 (141551410..141662153) |
Tissue Specificity
Highly expressed in muscle, heart, kidney and brain.
Subcellular Localizations
Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space. Localizes in the mitochondrion intermembrane space, where it associates with the inner membrane (PubMed:28712724). It is unclear whether the N-terminal hydrophobic region forms a transmembrane region or associates with the membrane without crossing it (PubMed:28712724, PubMed:28712726).
Diseases
- Malignant Neoplasms
- Prostatic Neoplasms
- Inflammation
- Malignant Neoplasm Of Prostate
- Neoplasms
- Intraepithelial Neoplasia
- Carcinoma
- Acidosis
- Cataract
- Hypertrophy
- Acidosis, Lactic
- Cataract And Cardiomyopathy
Pathways
- Secretion
- Cell Proliferation
- Coagulation
- Cell Cycle
- Pathogenesis
- Response To Superoxide
- Oxidative Phosphorylation
- Localization
- Platelet Aggregation
- Drug Resistance
PTMs
- Phosphorylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AGK
bosterbio.com/bosterbio-gene-info-cards/AGK
References
PMID: 16269826 by Van Overloop H., et al. Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies.
PMID: 15939762 by Bektas M., et al. A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells.