CC2D2A Antibodies

AND CC2D2A ELISA kits, CC2D2A Proteins

Many biological assays use antibodies to detect CC2D2A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CC2D2A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CC2D2A antibodies...

We validate the specificity of these antibodies to CC2D2A by testing them on tissues known to express CC2D2A positively and negatively. Browse below to find the CC2D2A antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CC2D2A Infographic by Boster Bio

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CC2D2A Overview

Facts about Coiled-coil and C2 domain-containing protein 2A.

CC2D2A 3D structure. Source: alphafold

Coiled-coil and C2 domain-containing protein 2A (CC2D2A)

Component of the tectonic-like complex, a complex localized in the transition zone of primary cilia and acting as a barrier which prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).

Gene Information

Human
Gene Name:	CC2D2A
Uniprot:	Q9P2K1
Entrez:	57545

Family

Belongs to:

No superfamily

Alternative Names

coiled-coil and C2 domain containing 2A

Molecular Weight

Mass (kDA):
186.185 kDA

Genomic Context


Human

Location:	4p15.32
Sequence:	4; NC_000004.12 (15468660..15601557)

Tissue Specificity

Strongly expressed in prostate, pancreas, kidney, lung, liver, retina, kidney, fetal brain and fetal kidney. Lower expression in spleen, small intestine, colon, skeletal muscle, ovary, thymus and heart.

Subcellular Localizations

Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Localizes at the transition zone, a region between the basal body and the ciliary axoneme.

Diseases

Familial Aplasia Of The Vermis
Cystic Kidney Diseases
Meckel-gruber Syndrome
Polydactyly
Kidney Diseases
Congenital Cerebral Hernia
Ciliary Motility Disorders
Fibrosis
Dystrophy
Hepatic Fibrosis
Retinal Dystrophies
Ataxia

Muscle Hypotonia
Liver Diseases
Nephronophthisis
Polycystic Kidney Diseases
Dysplasia
Developmental Delay (disorder)

Pathways

Transport
Cell Cycle
Brain Development
Cognition
Intraflagellar Transport
Protein Transport
Pathogenesis

Localization

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CC2D2A

References

PMID: 18513680 by Tallila J., et al. Identification of CC2D2A as a Meckel syndrome gene adds an important piece to the ciliopathy puzzle.

PMID: 18387594 by Noor A., et al. CC2D2A, encoding a coiled-coil and C2 domain protein, causes autosomal-recessive mental retardation with retinitis pigmentosa.