Cbx2 Antibodies

AND Cbx2 ELISA kits, Cbx2 Proteins

Many biological assays use antibodies to detect Cbx2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cbx2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cbx2 antibodies...

We validate the specificity of these antibodies to Cbx2 by testing them on tissues known to express Cbx2 positively and negatively. Browse below to find the Cbx2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Cbx2 Infographic by Boster Bio

All Cbx2 Products

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Product

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Specificity

Applications

Price

Anti-Chromobox protein homolog 2 CBX2 Antibody

Human, Mouse

ELISA, IHC

$380
Cat # A06356
100ul

Anti-CBX2 Rabbit Monoclonal Antibody

Human, Mouse, Rat

Flow Cytometry, WB

$370
Cat # M06356
100 μl/vial

Anti-CBX2 Antibody Picoband®

Human, Mouse

ELISA, IF, IHC, ICC, WB

$370
Cat # A06356-2
100 μg/vial

CBX2 (NM_005189) Human Over-expression Lysate

Human

$960
Cat # LS084733
100 µg

Cbx2 Overview

Facts about Chromobox protein homolog 2.

Chromobox protein homolog 2 (Cbx2)

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to keep the transcriptionally repressive state of many genes, including Hox genes, during development (By similarity). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity).

Binds to histone H3 trimethylated in'Lys-9' (H3K9me3) or at'Lys- 27' (H3K27me3) (PubMed:16537902). Plays a role in the lineage differentiation of the germ layers in embryonic development (PubMed:22226355).

Gene Information

Mouse
Gene Name:	Cbx2
Uniprot:	P30658
Entrez:	12416

Family

Belongs to:

No superfamily

Alternative Names

Cbx2; CDCA6; cell division cycle associated 6; chromobox homolog 2 (Drosophila Pc class); chromobox homolog 2 (Pc class homolog, Drosophila); chromobox homolog 2; chromobox protein homolog 2; M33; MGC10561; modifier 3; Pc class homolog; SRXY5

Molecular Weight

Mass (kDA):
54.918 kDA

Genomic Context


Mouse

Location:	11 E2\|11 83.33 cM
Sequence:	11;

Tissue Specificity

Expressed in embryoid bodies.

Diseases

Malignant Neoplasms
Carcinoma
Embryonal Carcinoma
Disorders Of Sex Development
Neoplasms
Tumor Progression
Malignant Neoplasm Of Breast
Teratogenic Effect
Osteosarcoma
Nervousness
Mammary Neoplasms
Chimera Disorder

Bipolar Disorder
Liver Regeneration Disorder
Mammary Neoplasms, Experimental
Cell Transformation, Neoplastic
Anemia
Genomic Instability
Malignant Paraganglionic Neoplasm

Pathways

Localization
Metaphase
Gene Silencing
Sex Determination
Interphase
Cell Proliferation
Heterochromatin Assembly
Protein Targeting
Histone Modification
Nuclear Export
Leydig Cell Differentiation
Cell Maturation
Cell Cycle

Prophase
Cell Differentiation
Chromatin Organization
Dna Methylation
Segment Specification
Larval Development
Methylation

PTMs

Methylation

Phosphorylation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Cbx2

References

PMID: 1352241 by Pearce J.J.H., et al. The mouse has a Polycomb-like chromobox gene.

PMID: 9312051 by Schoorlemmer J., et al. Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain.