CBLB Antibodies

AND CBLB ELISA kits, CBLB Proteins

Many biological assays use antibodies to detect CBLB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CBLB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CBLB antibodies...

We validate the specificity of these antibodies to CBLB by testing them on tissues known to express CBLB positively and negatively. Browse below to find the CBLB antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CBLB Infographic by Boster Bio

All CBLB Products

Product

Figures

Specificity

Applications

Price

Anti-CBLB Antibody

Human, Mouse

$405
Cat # A00735
100ul

CBLB (NM_170662) Human Over-expression Lysate

Human

$628
Cat # LS000868
100 µg

CBLB Overview

Facts about E3 ubiquitin-protein ligase CBL-B.

CBLB 3D structure. Source: alphafold

E3 ubiquitin-protein ligase CBL-B (CBLB)

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways.

In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and following activation.

Gene Information

Human
Gene Name:	CBLB
Uniprot:	Q13191
Entrez:	868

Family

Belongs to:

No superfamily

Alternative Names

Cas-Br-M (murine) ecotropic retroviral transforming sequence b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; Casitas B-lineage lymphoma proto-oncogene b; DKFZp686J10223; DKFZp779A0729; DKFZp779F1443; E3 ubiquitin-protein ligase CBL-B; EC 6.3.2; EC 6.3.2.-; FLJ41152; RING finger protein 56; RNF56FLJ36865; SH3-binding protein CBL-B; Signal transduction protein CBL-B

Molecular Weight

Mass (kDA):
109.45 kDA

Genomic Context


Human

Location:	3q13.11
Sequence:	3; NC_000003.12 (105655461..105869552, complement)

Tissue Specificity

Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle. Present in lymphocytes (at protein level).