Caspase-14 Antibodies

Caspase-14 (Casp14)

Non-apoptotic caspase that's involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification (PubMed:18156206).

Regulates maturation of the skin by proteolytically processing filaggrin (PubMed:21654840). In vitro is equally busy on the synthetic caspase substrates WEHD-ACF and IETD-AFC.

Gene Information

Mouse
Gene Name:	Casp14
Uniprot:	O89094
Entrez:	12365

Family

Belongs to:
peptidase C14A family

Alternative Names

apoptosis-related cysteine protease; CASP14; CASP-14; caspase 14, apoptosis-related cysteine peptidase; caspase 14, apoptosis-related cysteine protease; Caspase14; Caspase-14; EC 3.4.22.-; MGC119078; MGC119079; MICE

Molecular Weight

Mass (kDA):
29.458 kDA

Genomic Context

Mouse
Location:	10|10 C1
Sequence:	10;

Tissue Specificity

Embryo, adult liver and less in adult brain and kidney. Expressed in differentiating keratinocytes of embryonic skin (at protein level). Expressed in keratinocytes of adult skin suprabasal layers (at protein level).

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Psoriasis
• Malignant Neoplasm Of Breast
• Myeloid Leukemia, Chronic
• Myeloid Leukemia
• Mammary Neoplasms
• Hematologic Neoplasms
• Leukemia
• Malignant Tumor Of Cervix
• Neoplasms, Glandular And Epithelial

• Inflammation
• Dehydration
• Leukemia, Myelocytic, Acute
• Malignant Squamous Cell Neoplasm
• Cell Transformation, Neoplastic
• Skin Neoplasms
• Hypertrichosis

Pathways

• Cell Death
• Keratinocyte Differentiation
• Cornification
• Programmed Cell Death
• Localization
• Cell Cycle
• Cell Differentiation
• Epithelial Cell Differentiation
• Keratinization
• Hair Follicle Morphogenesis
• Hair Follicle Development
• Cell Proliferation
• Induction Of Apoptosis

• Immune Response
• Proteolysis
• Dna Repair
• Cell Cycle Arrest
• Senescence
• Response To Ionizing Radiation
• S Phase

PTMs

• Cleavage

• Dephosphorylation

Research Areas

• Apoptosis
• Cancer
• Caspases

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Casp14

Boster Bio - Best Uses Of The CASP14 Marker

Boster, a biomedical researcher as well as author, has been featured in NPR, CNN, and BBC. Here we explore historie, current position, as well as future plans. We also discuss his participation in the CASP14 baking competition and the Boster Bio. We conclude that Boster has had a long and distinguished career. It is fascinating to read his bio!

Historie

The Historie involving the CASP14 Marker is an interesting example. It unites several previously unresolved genetic regions into a single structure. This increased the sensitivity of CASP14 (an enzyme that is involved in deposition of DNA within cells), which was also improved. It has also performed well in CAMEO benchmarks. There is more to this gene that its appearance in DNA.

The folding of proteins is analogous with a spatial graph. It can be used to better understand physical interaction and evolutionary history. DeepMind employed new deep-learning architectures to create an algorithm for CASP14 that achieved the highest level possible accuracy among participants. They were inspired by the work that proteins folding scientists have done over the last 50 years. Multiple sequence alignments and representations of amino acid residue pairs are used in the algorithm.

Current position

The CASP14 marker's current position is an important part of the human genome. It influences the expression and function of cancer-related gene. You will need to know the sequence and origin of the CASP14 marker in order to determine its exact location. Then you will need information about how the protein binds. PDB provides the structure of CASP14. It is also necessary to know its ligands in order to identify its targets.

In recent years, structure prediction technology has advanced dramatically. The CASP14 benchmark, which was published recently, highlights significant progress in this field. AlphaFold, which was a new algorithm, won the CASP13 benchmark with the highest accuracy. The AlphaFold system used a different model than the one used in CASP13, and demonstrated its high accuracy. Backbone predictions that have sub-Angstrom root mean sq deviation are now the norm. Accurate side chains are also becoming common. These new techniques are capable of producing excellent results even for proteins without template structures.

Future plans

The CASP14 marker was scheduled to begin in mid-April 2020. However, it has been delayed by the COVID-19 complication. The conference will focus on contact predictions. However there are plans to expand these categories to include interresidue-distance predictions. Below are future plans for the CASP14 mark. Visit the CASP14 format page for more information. After that, the format will be open to submission in March orApril 2020.

The CASP14 protein structure modeler is being developed. Scientists from 100 different research groups around the world are invited to submit sequences containing unstructured proteins for modeling. These models are then validated by independent assessors as soon as the experimental coordinates are available. The CASP14 marker will appear in a special issue for PROTEINS.