Caspase-12 Antibodies

Caspase-12 (Casp12)

Involved in the activation cascade of caspases responsible for apoptosis execution. .

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Gene Information

Mouse
Gene Name:	Casp12
Uniprot:	O08736
Entrez:	12364

Family

Belongs to:
peptidase C14A family

Alternative Names

Apoptosis Related Cysteine Protease; CASP 12; CASP12; CASP12P1; Caspase 12 pseudogene 1; Caspase12; Caspase-12; UNQ9415

Molecular Weight

Mass (kDA):
47.854 kDA

Genomic Context

Mouse
Location:	9 A1|9 2.46 cM
Sequence:	9;

Tissue Specificity

Mainly expressed in skeletal muscle and lung.

Diseases

• Endoplasmic Reticulum Stress
• Physiological Stress
• Inflammation
• Neurodegenerative Disorders
• Malignant Neoplasms
• Systemic Infection
• Alzheimer's Disease
• Neoplasms
• Ischemia
• Nerve Degeneration
• Mitochondrial Damage
• Neurotoxicity Syndromes
• Infarction

• Neuroblastoma
• Sclerosis
• Primary Lateral Sclerosis
• Amyotrophic Lateral Sclerosis
• Diabetes Mellitus
• Cerebral Ischemia
• Hypoxia

Pathways

• Cell Death
• Pathogenesis
• Programmed Cell Death
• Immune Response
• Translation
• Cell Proliferation
• Proteolysis
• Induction Of Apoptosis
• Rna Interference
• Transport
• Cell Cycle
• Cell Growth
• Apoptotic Process

• Secretion
• Glycosylation
• Protein Transport
• Protein Folding
• Tissue Homeostasis
• Aging
• Hypersensitivity

PTMs

• Cleavage
• Phosphorylation
• Ubiquitination

• Reduction
• Glycosylation
• Oxidation

Research Areas

• Apoptosis
• Cancer
• Caspases

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Casp12

Best Uses Of The CASP12 Marker

This article will focus on Steven Boster's CASP12 marker and his work in Nature Biotech 2013. Josh Weinstein, David Scott, and others have developed a data analysis pipeline. These articles are intended to help you understand the CASP12 genome and its role in cell biology. I hope you have found these articles helpful. I hope you enjoy the rest and find it as fascinating as I did.

Steven Boster

Steve Boster, a Staunton-area retired retail manager, is known as a Road Warrior. His career spanned 30 years. He was a veteran of the U.S. Army, and a member of Concordia Hall in Staunton. His family includes Crystal and Natosha Peck's daughters, six grandchildren, as well as four brothers. He is also survived by his sister Kimberly and daughter-in-law Lisa Milton.

CASP12 marker

The latest experiment for the CASP12 marker released eighty two unique protein sequences for prediction targets. Organizers had no reference structures or tertiary assessors to cancel eleven of these predicted targets. One target was also canceled because its monomeric structure is unsuitable for prediction. But what are the best uses of the CASP12 marker? Let's take a look.

The fourth-ranked ProQ2 model in the CASP11 rankings had a accuracy loss of 6.4 GDTTS units, which is 22% more than the best CASP12 result. This result indicates that CASP12 targets are more difficult to accurately model than CASP11 targets, which would explain the larger loss in accuracy. The CASP12 marker is an excellent candidate for predicting human protein expression levels.

CASP12 accuracy is estimated by a CASP12 predictor who submits global accuracy estimates in two steps. The groups are sorted according to the difference in average accuracy between stage one and stage two. The red horizontal line represents the difference in accuracy between stage one and stage two. The separation line is divided into two parts: single-model and clustering models are on the opposite sides, and quasi-single or multi-model methods on both.

CASP12 had significant improvements over CASP11. The results of CASP12 were significantly better than CASP11. They can also differentiate between good models and bad models. ModFOLD6 and Davis EMAconsensus methods are especially sensitive to the model environment. These two methods are the most efficient overall. The outline and color of the CASP12 markers can help you distinguish between single-model models and the best models.

Nature Biotech 2013

Nature Biotech published a paper that describes the first structural analysis on the CASP12 protein. These studies prove that CASP12 has the ability to identify target proteins through their peptide sequencings. The authors discuss the most striking structural features of target proteins and assess whether they were reproduced accurately by predictions submitted to CASP12. This gene is an important marker to identify cancer genes.

David Scott, Josh Weinstein and Josh Weinstein created a data analysis process

David Scott and Josh Weinenstein developed the data analysis pipeline to provide a consistent and reproducible structure for astronomical data management. The pipeline includes everything from the planning of observations to the publication and analysis of data. The pipeline provides an excellent teaching platform for IRAF and encapsulates the policy and processing decisions within a transparent and auditable environment. The pipeline allows for rapid image processing and offers a great teaching environment for astronomical information management.