Caspase recruitment domain-containing protein 14 (CARD14)

Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Types a signaling complex with BCL10 and MALT1, and triggers MALT1 proteolytic activity and inflammatory gene expression.

MALT1 is crucial for CARD14- induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27113748, PubMed:27071417). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.