Cullin-associated NEDD8-dissociated protein 1 (CAND1)

Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a crucial role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange element.

The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of their F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.