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Facts about Calmodulin-regulated spectrin-associated protein 3.
Additionally, it also decreases the speed of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the upkeep of zonula adherens by anchoring the minus-end of microtubules into zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755).
Human | |
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Gene Name: | CAMSAP3 |
Uniprot: | Q9P1Y5 |
Entrez: | 57662 |
Belongs to: |
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CAMSAP1 family |
calmodulin regulated spectrin-associated protein family, member 3; calmodulin-regulated spectrin-associated protein 3; KIAA1543; NEZHA; protein Nezha
Mass (kDA):
134.75 kDA
Human | |
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Location: | 19p13.2 |
Sequence: | 19; NC_000019.10 (7595863..7618304) |
Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cytoplasm. Scattered in the cytoplasm, associated with the minus-end of microtubules and also detected at the centrosomes (PubMed:19041755, PubMed:24486153, PubMed:27693509). Decorates the minus-end of microtubules by decreasing the rate of tubulin incorporation and remaining bound (PubMed:24486153). Localizes along zonula adherens only at mature cell-cell contacts (PubMed:19041755). In early embryos, accumulates at the microtubule bridges that connect pairs of cells: this structure is present in early embryos, which lack centrosomes (
PMID: 19041755 by Meng W., et al. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts.
PMID: 23169647 by Tanaka N., et al. Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules.