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- Table of Contents
Facts about Voltage-dependent calcium channel subunit alpha-2/delta-2.
Overexpression induces apoptosis. .
Human | |
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Gene Name: | CACNA2D2 |
Uniprot: | Q9NY47 |
Entrez: | 9254 |
Belongs to: |
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calcium channel subunit alpha-2/delta family |
alpha 2 delta calcium channel subunit; CACNA2D; calcium channel, voltage-dependent, alpha 2/delta subunit 2; gene 26; KIAA0558Voltage-gated calcium channel subunit alpha-2/delta-2; LUAC11.1; voltage-dependent calcium channel subunit alpha-2/delta-2
Mass (kDA):
129.817 kDA
Human | |
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Location: | 3p21.31 |
Sequence: | 3; NC_000003.12 (50362613..50504244, complement) |
Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain.
Membrane; Single-pass type I membrane protein. Colocalizes with CACNA1A in lipid raft fractions.
PMID: 9880589 by Klugbauer N., et al. Molecular diversity of the calcium channel alpha2delta subunit.
PMID: 10766861 by Gao B., et al. Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2).