CACNA2D2 Antibodies

Voltage-dependent calcium channel subunit alpha-2/delta-2 (CACNA2D2)

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and maybe T-type (CACNA1G).

Overexpression induces apoptosis. .

Gene Information

Human
Gene Name:	CACNA2D2
Uniprot:	Q9NY47
Entrez:	9254

Family

Belongs to:
calcium channel subunit alpha-2/delta family

Alternative Names

alpha 2 delta calcium channel subunit; CACNA2D; calcium channel, voltage-dependent, alpha 2/delta subunit 2; gene 26; KIAA0558Voltage-gated calcium channel subunit alpha-2/delta-2; LUAC11.1; voltage-dependent calcium channel subunit alpha-2/delta-2

Molecular Weight

Mass (kDA):
129.817 kDA

Genomic Context

Human
Location:	3p21.31
Sequence:	3; NC_000003.12 (50362613..50504244, complement)

Tissue Specificity

Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain.

Subcellular Localizations

Membrane; Single-pass type I membrane protein. Colocalizes with CACNA1A in lipid raft fractions.

Diseases

• Neoplasms
• Malignant Neoplasms
• Epilepsy
• Lung Neoplasms
• Malignant Neoplasm Of Lung
• Carcinogenesis
• Absence Epilepsy
• Ataxia
• Carcinoma
• Pain
• Malignant Neoplasm Of Breast
• Non-small Cell Lung Carcinoma

• Cerebellar Ataxia
• Small Cell Carcinoma Of Lung
• Nervousness
• Tissue Adhesions
• Neoplasm Metastasis
• Epilepsy, Generalized

Pathways

• Methylation
• Cell Proliferation
• Cell Growth
• Localization
• Cell Cycle
• Pathogenesis
• Induction Of Apoptosis
• Signal Transmission
• Dna Methylation
• Membrane Depolarization
• Mrna Splicing

• Translation
• Cell Death
• Angiogenesis
• Histone Methylation
• Exocytosis

PTMs

• Methylation
• Demethylation
• Cleavage

• Reduction
• Acetylation
• Gpi Anchoring

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CACNA2D2

Best Uses Of The CACNA2D2 Marker From Steven Boster

Anti-CACNA2D2 is a marker discovered by Steven Boster. We will discuss its use in calcium signaling pathways, its time in Boster's laboratory, and its roots as an adenovirus-mediated viral vector. Let's get started! What is the CACNA2D2 marker? And how does it work in your lab?

Anti-CACNA2D2 marker by Steven Boster

The Anti-CACNA2D2 antibodies developed by Steven Boster has been validated for use in ELISA, Flow Cytometry and IHC applications. This antibody recognizes CaVa2d2, which is a calcium channel subunit that is voltage-dependent from alpha/delta-2. The antiserum could have orthologs in different species, like human cells and monkeys.

Cacna2D2 antibodies are available in the 10 ug or bundle form. The antibodies are validated using known negative and positive samples. The specificity and affinity are then confirmed. The company rewards first reviewers with product credits, and it also provides the scientists with free samples all over the world. It has been established that Cacna2D2 is an important factor in determining the size of the tumor cells.

It is utilized in calcium signaling pathways.

CACNA2D2 could be described as a calcium channel with a voltage-gated function. This ion channel plays an important role in the pathogenesis and causes of many neurological disorders, including epilepsy. It could be helpful in the development of therapies targeted at this protein. This marker can be used to identify calcium signaling pathway proteins. They may be useful in the development of new treatments.

CACNA2D2 is located in the cytosols and cytosols of an unresponsive cells and is expressed in numerous cell types, including lung carcinoma. Selective inhibitors of VACC subtypes inhibit it. CACNA2D2 also regulates cell proliferation and even death. In addition, CACNA2D2 has physiological functions in the body , and could be involved in calcium signaling pathways.

CACNA2D2 has been proven to cause anapoptosis. It is used to study the interactions of CACNA2D2 and mitochondrial membrane integrity. Furthermore, CACNA2D2 is related to calcium levels and mitochondrial membrane integrity and mitochondrial membrane integrity, two processes that contribute to the process of apoptosis. These results highlight the importance of CACNA2D2 in calcium signaling pathways.

The marker CACNA2D2 has been used to identify many proteins involved with calcium Gating in the cell. Alternative splicing of the C-terminal regulatory area of CaV1.3 L type calcium channels can alter their gating capabilities. In addition to regulating calcium levels, the CaCNA2D2 marker can also be used to search for mutations in CACNA2D2 gene.

Its origins are in a ligation-mediated plasmid adenovirus vector

The Adenoviral viruses have made significant advances in medical research as well as the treatment of a variety of difficult conditions. It is used as a delivery system for genetic material. In recent times it has also been used in gene therapy. It's not without controversy. Despite this controversy the adenoviral vector has assisted scientists in finding ways to treat diseases by transferring their genetic material.

Recombinant adenoviruses are a boon for many reasons they can provide, such as the ability to express genes in different cell types without active cell division. They allow the production of multiple transgenes in the same virus. Recombinant adenoviruses, in contrast to the ligationmediated plasmid vector, can generate high levels of transgene expression and titers.

Large genomes of viruses can now be modified with BACs. In addition, BACs could be used as recombination vectors. Recombinant adenoviruses may also be utilized as vectors that can be recombinant. These viruses were first obtained by artificial synthesis and amplification, before being rescued using conventional restriction enzyme the cloning.

Adenoviral plasmids can be used to transfer gene therapy, recombinant vaccines as well as cancer treatments. Adenoviral vectors have been extensively utilized in cell-based and vaccine medicine. Adenovirus vectors have numerous advantages over other viral vectors.

The capsid of the adenovirus, also referred to as adenovirus, is a non-enveloped virus. It is comprised of 240 hexon proteins, which are referred to as capsomers. The capsids are then inserted into cells targeted by the membrane. The penton capsomere, composed of five copies of penton base and three copies of fiber, is then delivered to the endosome where it releases the viral particles.

The pShuttle is a plasmid that was used to control the expression of the kanamycin resistance gene. It also contains the source of replication pBR322 (Life Technologies) as an efficient method for producing large recombinant adenoviruses. Its roots are in a ligation-mediated vector plasmid Adenovirus.