CACNA2D1 Antibodies

AND CACNA2D1 ELISA kits, CACNA2D1 Proteins

Many biological assays use antibodies to detect CACNA2D1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CACNA2D1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CACNA2D1 antibodies...

We validate the specificity of these antibodies to CACNA2D1 by testing them on tissues known to express CACNA2D1 positively and negatively. Browse below to find the CACNA2D1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CACNA2D1 Infographic by Boster Bio

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Anti-Cacna2d1 Antibody

1 Q&As

Human, Mouse, Rat

ELISA, WB

$335
Cat # A04282-2
100ul

CACNA2D1 Overview

Facts about Voltage-dependent calcium channel subunit alpha-2/delta-1.

CACNA2D1 3D structure. Source: alphafold

Voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1)

The alpha-2/delta subunit of voltage-dependent calcium channels modulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).

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Gene Information

Human
Gene Name:	CACNA2D1
Uniprot:	P54289
Entrez:	781

Family

Belongs to:

calcium channel subunit alpha-2/delta family

Alternative Names

CACNA2; CACNL2Adihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit; calcium channel, L type, alpha 2 polypeptide; calcium channel, voltage-dependent, alpha 2/delta subunit 1; CCHL2A; MHS3; voltage-dependent calcium channel subunit alpha-2/delta-1; Voltage-gated calcium channel subunit alpha-2/delta-1

Molecular Weight

Mass (kDA):
124.568 kDA

Genomic Context


Human

Location:	7q21.11
Sequence:	7; NC_000007.14 (81946444..82443956, complement)

Tissue Specificity

Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

Pain
Neuralgia
Nervousness
Peripheral Neuropathy
Epilepsy
Anxiety Disorders
Hyperalgesia
Nerve Damage
Malignant Neoplasms
Neoplasms
Partial Seizure
Cardiac Arrhythmia

Diabetic Neuropathies
Ventricular Fibrillation
Hyperalgesia, Tactile
Tissue Adhesions
Postherpetic Neuralgia
Chronic Pain

Pathways

Localization
Sensitization
Hypersensitivity
Transport
Cell Proliferation
Muscle Contraction
Methylation
Membrane Depolarization
Cell Growth
Proteolysis
Endocytosis
Reverse Transcription

System Development
Nervous System Development
Vasoconstriction
Angiogenesis
Exocytosis
Pathogenesis
Secretion

PTMs

Cleavage
Methylation

Gpi Anchoring
Phosphorylation

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CACNA2D1

References

PMID: 1309651 by Williams M.E., et al. Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype.

PMID: 8107964 by Brust P.F., et al. Human neuronal voltage-dependent calcium channels: studies on subunit structure and role in channel assembly.