CACNB1 Antibodies

AND CACNB1 ELISA kits, CACNB1 Proteins

Many biological assays use antibodies to detect CACNB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CACNB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CACNB1 antibodies...

We validate the specificity of these antibodies to CACNB1 by testing them on tissues known to express CACNB1 positively and negatively. Browse below to find the CACNB1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CACNB1 Infographic by Boster Bio

All CACNB1 Products

Product

Figures

Specificity

Applications

Price

CACNB1 (NM_199247) Human Recombinant Protein

$1249
Cat # PROTQ02641
20 µg

Anti-CACNB1 Mouse Monoclonal Antibody [Clone ID: OTI3H6]

Human, Mouse

$523
Cat # M05080
100 µl

CACNB1 (NM_199247) Human Over-expression Lysate

Human

$960
Cat # LS000782
100 µg

CACNB1 Overview

Facts about Voltage-dependent L-type calcium channel subunit beta-1.

CACNB1 3D structure. Source: alphafold

Voltage-dependent L-type calcium channel subunit beta-1 (CACNB1)

Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:8107964, PubMed:15615847). Regulates the activity of L-type calcium channels that contain CACNA1A as pore- forming subunit (By similarity).

Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for practical expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651).

Gene Information

Human
Gene Name:	CACNB1
Uniprot:	Q02641
Entrez:	782

Family

Belongs to:

calcium channel beta subunit family

Alternative Names

CAB1; CACNLB1calcium channel, L type, beta 1 polypeptide; Calcium channel voltage-dependent subunit beta 1; calcium channel, voltage-dependent, beta 1 subunit; CCHLB1; dihydropyridine-sensitive L-type, calcium channel beta-1 subunit; MGC41896; voltage-dependent L-type calcium channel subunit beta-1

Molecular Weight

Mass (kDA):
65.714 kDA

Genomic Context


Human

Location:	17q12
Sequence:	17; NC_000017.11 (39173453..39197669, complement)

Tissue Specificity

Detected in heart ventricle (at protein level) (PubMed:15615847). Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle.

Subcellular Localizations

Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein.

Diseases

Disease Of Adrenal Medulla
Malnutrition
Weakness
Metabolic Acidosis
Cardiac Complication
Rheumatism
Cerebrovascular Accident
Febrile Convulsions
Ischemic Stroke
Neuroblastoma
Acidosis
Atrial Fibrillation

Nervous System Disorder
Tissue Adhesions
Acidemia
Diabetes Mellitus
Cardiac Fibrillation
Epilepsy
Major Depressive Disorder

Interacting Proteins

CACNA1C

Pathways

Transport
Cell Adhesion
Aging
Ion Transport
Synaptic Transmission
Neurogenesis
Localization
Membrane Depolarization
Reverse Transcription

Cell Death
Pathogenesis
Innervation
Response To Antidepressant

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CACNB1

References

PMID: 1385409 by Powers P.A., et al. Skeletal muscle and brain isoforms of a beta-subunit of human voltage-dependent calcium channels are encoded by a single gene.

PMID: 1309651 by Williams M.E., et al. Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype.