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CACNA1D Antibodies
AND CACNA1D ELISA kits, CACNA1D Proteins
Many biological assays use antibodies to detect CACNA1D, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CACNA1D in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CACNA1D antibodies...
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CACNA1D Infographic by Boster Bio
All CACNA1D Products
Product
Figures
Specificity
Applications
Price
Anti-CaV1.3/CACNA1D Antibody Picoband®
1 Citations 7 Q&As
Human, Mouse, Rat
WB
$370
Cat # PA2293
100 μg/vial
Cat # PA2293
100 μg/vial
Anti-CaV1.3/CACNA1D Antibody Picoband®
1 Citations 1 Q&As
Human, Mouse, Rat
Flow Cytometry, IHC, ICC, WB
$370
Cat # PB9329
100 μg/vial
Cat # PB9329
100 μg/vial
CACNA1D Overview
Facts about Voltage-dependent L-type calcium channel subunit alpha-1D.
Voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D)
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in many different calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents.
Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines.
Gene Information
| Human | |
|---|---|
| Gene Name: | CACNA1D |
| Uniprot: | Q01668 |
| Entrez: | 776 |
Family
| Belongs to: |
|---|
| calcium channel alpha-1 subunit (TC 1.A.1.11) family |
Alternative Names
CACN4calcium channel, neuroendocrine/brain-type, alpha 1 subunit; CACNL1A2voltage-dependent L-type calcium channel subunit alpha-1D; Calcium channel, L type, alpha-1 polypeptide, isoform 2; calcium channel, voltage-dependent, L type, alpha 1D subunit; Cav1.3; CCHL1A2voltage-gated calcium channel alpha 1 subunit; L type, alpha-1 polypeptide; voltage-gated calcium channel alpha subunit Cav1.3; Voltage-gated calcium channel subunit alpha Cav1.3
Molecular Weight
Mass (kDA):
245.141 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p21.1 |
| Sequence: | 3; NC_000003.12 (53494611..53813733) |
Tissue Specificity
Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle.
Subcellular Localizations
Membrane; Multi-pass membrane protein.
Diseases
- Complete Hearing Loss
- Bradycardia
- Parkinson Disease
- Nervousness
- Cardiac Fibrillation
- Atrial Fibrillation
- Diabetes Mellitus
- Cardiac Arrhythmia
- Atrioventricular Block
- Pain
- Diabetes Mellitus, Non-insulin-dependent
- Physical Dependence
Pathways
- Secretion
- Localization
- Exocytosis
- Insulin Secretion
- Aging
- Synaptic Transmission
- Sensitization
- Catecholamine Secretion
- Pathogenesis
- Transport
- Muscle Contraction
- Membrane Depolarization
- Neuroprotection
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CACNA1D
bosterbio.com/bosterbio-gene-info-cards/CACNA1D
References
PMID: 1309651 by Williams M.E., et al. Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype.
PMID: 1309948 by Seino S., et al. Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells.
1 Publications of Boster CACNA1D Antibodies & ELISA Kits
- PubMed ID: 28656274, Guo, Y., Cui, L., Jiang, S., Zhang, A., & Jiang, S. (2017). Proteomics of acute ...
*More publications can be found for each product on its corresponding product page