CACNA1B Antibodies

AND CACNA1B ELISA kits, CACNA1B Proteins

Many biological assays use antibodies to detect CACNA1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CACNA1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CACNA1B antibodies...

We validate the specificity of these antibodies to CACNA1B by testing them on tissues known to express CACNA1B positively and negatively. Browse below to find the CACNA1B antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CACNA1B Infographic by Boster Bio

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CACNA1B Overview

Facts about Voltage-dependent N-type calcium channel subunit alpha-1B.

CACNA1B 3D structure. Source: alphafold

Voltage-dependent N-type calcium channel subunit alpha-1B (CACNA1B)

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents.

N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (AC P01522) (By similarity). They are however insensitive to dihydropyridines (DHP).

Gene Information

Human
Gene Name:	CACNA1B
Uniprot:	Q00975
Entrez:	774

Family

Belongs to:

calcium channel alpha-1 subunit (TC 1.A.1.11) family

Alternative Names

BIII; Brain calcium channel III; CACNL1A5calcium channel, L type, alpha-1 polypeptide; CACNN; calcium channel alpha12.2 subunit; calcium channel, N type; calcium channel, voltage-dependent, alpha 1B subunit, N type; calcium channel, voltage-dependent, L type, alpha 1B subunit; calcium channel, voltage-dependent, N type, alpha 1B subunit; Cav2.2 voltage-gated Ca2+ channel; Cav2.2; L type, alpha-1 polypeptide isoform 5; voltage-dependent N-type calcium channel subunit alpha-1B; Voltage-gated calcium channel subunit alpha Cav2.2

Molecular Weight

Mass (kDA):
262.496 kDA

Genomic Context


Human

Location:	9q34.3
Sequence:	9; NC_000009.12 (137877782..138124619)

Tissue Specificity

Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Pain
Nervousness
Neuralgia
Ataxia
Epilepsy
Schizophrenia
Sclerosis
Cerebellar Ataxia
Hyperalgesia
Chronic Pain
Bipolar Disorder

Autoimmune Reaction
Primary Lateral Sclerosis
Spinal Cord Injuries
Amyotrophic Lateral Sclerosis
Stress, Psychological
Lambert-eaton Myasthenic Syndrome

Interacting Proteins

Ppm1a
RXRB

Pathways

Synaptic Transmission
Secretion
Hypersensitivity
Long-term Memory
Exocytosis
Localization
Vesicle Fusion
Innervation
Transport
Habituation
Brain Development
Clustering Of Voltage-gated Calcium Channels
Glucose Homeostasis

Translation
Cognition
Glucagon Secretion
Prepulse Inhibition
Endocytosis
Vesicle Docking
Rna Splicing

PTMs

Phosphorylation

Biotinylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CACNA1B

References

PMID: 1321501 by Williams M.E., et al. Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel.

PMID: 9030575 by Kim D.S., et al. Isolation and characterization of the 5'-upstream region of the human N-type calcium channel alpha1B subunit gene. Chromosomal localization and promoter analysis.