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Calcium-binding protein 1 Antibodies
AND CABP1 ELISA kits, Calcium-binding protein 1 Proteins
Many biological assays use antibodies to detect Calcium-binding protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Calcium-binding protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Calcium-binding protein 1 antibodies...
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CABP1 Overview
Facts about Calcium-binding protein 1.
Calcium-binding protein 1 (CABP1)
Modulates calcium-dependent action of inositol 1,4,5- triphosphate receptors (ITPRs)(PubMed:14570872). Inhibits agonist- induced intracellular calcium signaling (PubMed:15980432).
Enhances inactivation and doesn't support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed:11865310). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin from the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed:15140941).
Gene Information
| Human | |
|---|---|
| Gene Name: | CABP1 |
| Uniprot: | Q9NZU7 |
| Entrez: | 9478 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CaBP1; CALBRAIN; calcium binding protein 1; calcium binding protein 5; calcium-binding protein 1; caldendrin; HCALB_BR
Molecular Weight
Mass (kDA):
39.838 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.31 |
| Sequence: | 12; NC_000012.12 (120640552..120680869) |
Tissue Specificity
Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.
Subcellular Localizations
Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Cell junction, synapse, postsynaptic density. L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane.; [Isoform L-CaBP1]: Cytoplasm, cytoskeleton. L-CaBP1 is associated most likely with the cytoskeletal structures.; [Isoform S-CaBP1]: Cytoplasm, cell cortex. Cell membrane; Lipid-anchor. S-CaBP1 is localized at or near the plasma membrane.
Diseases
- Nervousness
- Depressive Disorder
- Multiple Acyl Coenzyme A Dehydrogenase Deficiency
- Influenza
- Paroxysmal Nocturnal Dyspnea
- Inflammation
- Pathological Dilatation
- Hyperplasia
Interacting Proteins
- CACNA1C
Pathways
- Localization
- Synaptic Transmission
- Translation
- Secretory Pathway
- Protein Folding
- Secretion
- Transport
- Vesicle Transport
- Biosynthetic Process
- Hormone Biosynthetic Process
- Chemotaxis
- Cytokine Production
PTMs
- Phosphorylation
- Myristoylation
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CABP1
bosterbio.com/bosterbio-gene-info-cards/CABP1
References
PMID: 9920909 by Yamaguchi K., et al. Calbrain, a novel two EF-hand calcium-binding protein that suppresses Ca2+/calmodulin-dependent protein kinase II activity in the brain.
PMID: 10625670 by Haeseleer F., et al. Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin.