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MAPK8IP1 Antibodies
AND MAPK8IP1 ELISA kits, MAPK8IP1 Proteins
Many biological assays use antibodies to detect MAPK8IP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAPK8IP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAPK8IP1 antibodies...
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MAPK8IP1 Infographic by Boster Bio
All MAPK8IP1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A05068T103
100ul
Cat # A05068T103
100ul
Human, Mouse, Rat
IHC, WB
$523
Cat # M05068
100 µl
Cat # M05068
100 µl
MAPK8IP1 Overview
Facts about C-Jun-amino-terminal kinase-interacting protein 1.
C-Jun-amino-terminal kinase-interacting protein 1 (MAPK8IP1)
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress.
Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also take part in ApoER2-specific reelin signaling.
Gene Information
| Human | |
|---|---|
| Gene Name: | MAPK8IP1 |
| Uniprot: | Q9UQF2 |
| Entrez: | 9479 |
Family
| Belongs to: |
|---|
| JIP scaffold family |
Alternative Names
IB1; JIP1; MAPK8IP1; PRKM8IP
Molecular Weight
Mass (kDA):
77.524 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p11.2 |
| Sequence: | 11; NC_000011.10 (45885651..45906465) |
Tissue Specificity
Highly expressed in brain. Expressed in neurons, localizing to neurite tips in differentiating cells. Also expressed in the pancreas, testis and prostate. Low levels in heart, ovary and small intestine. Decreased levels in pancreatic beta cells sensitize cells to IL-1-beta-induced apoptosis.
Subcellular Localizations
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Endoplasmic reticulum membrane. Mitochondrion membrane. Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity).
Diseases
- Alzheimer's Disease
- Neoplasms
- Diabetes Mellitus
- Malignant Neoplasms
- Neuroblastoma
- Carcinoma
- Diabetes Mellitus, Non-insulin-dependent
- Potocki-shaffer Syndrome
- Malignant Paraganglionic Neoplasm
- Prostatic Neoplasms
- Exostoses
- Carcinogenesis
Interacting Proteins
- App
- EGFR
- ERBB2
- MAP2K7
- MAP3K7
- MAPK8
Pathways
- Cell Death
- Pathogenesis
- Transport
- Cell Cycle
- Cell Proliferation
- Localization
- Secretion
- Protein Phosphorylation
- Hyperphosphorylation
- Programmed Cell Death
- Response To Stress
- Induction Of Apoptosis
- Signal Transmission
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAPK8IP1
bosterbio.com/bosterbio-gene-info-cards/MAPK8IP1
References
PMID: 9933567 by Mooser V., et al. Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/C-jun-amino-terminal kinase interacting protein-1 (JIP-1) gene.
PMID: 10574993 by Meyer D., et al. Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons.