This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about C5a anaphylatoxin chemotactic receptor 1.
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009).
The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and another site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099).Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion generation (PubMed:10636859, PubMed:15153520). .
Human | |
---|---|
Gene Name: | C5AR1 |
Uniprot: | P21730 |
Entrez: | 728 |
Belongs to: |
---|
G-protein coupled receptor 1 family |
C5a anaphylatoxin chemotactic receptor; C5A; C5aR; C5a-R; C5AR1; C5ARC5a anaphylatoxin receptor; C5R1C5a ligand; CD88 antigen; CD88; complement component 5 receptor 1 (C5a ligand); complement component 5 receptor 1; complement component 5a receptor 1; Complement Component C5a R1; Complement Component C5aR1
Mass (kDA):
39.336 kDA
Human | |
---|---|
Location: | 19q13.32 |
Sequence: | 19; NC_000019.10 (47309861..47322066) |
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles.
PMID: 2007135 by Boulay F., et al. Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells.
PMID: 1847994 by Gerard N.P., et al. The chemotactic receptor for human C5a anaphylatoxin.